Ho KY - Search Results

1

Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.

Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radić Z. Blumenthal DK, et al. Among authors: ho ky. J Biol Chem. 2021 Sep;297(3):101007. doi: 10.1016/j.jbc.2021.101007. Epub 2021 Jul 27. J Biol Chem. 2021. PMID: 34324828 Free PMC article.

2

Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors.

Talley TT, Olivera BM, Han KH, Christensen SB, Dowell C, Tsigelny I, Ho KY, Taylor P, McIntosh JM. Talley TT, et al. Among authors: ho ky. J Biol Chem. 2006 Aug 25;281(34):24678-86. doi: 10.1074/jbc.M602969200. Epub 2006 Jun 27. J Biol Chem. 2006. PMID: 16803900 Free PMC article.

3

Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions.

Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, Taylor P. Talley TT, et al. Among authors: ho ky. Biochemistry. 2006 Jul 25;45(29):8894-902. doi: 10.1021/bi060534y. Biochemistry. 2006. PMID: 16846232 Free PMC article.

4

Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.

Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. Cochran R, et al. Among authors: ho ky. J Biol Chem. 2011 Aug 26;286(34):29718-24. doi: 10.1074/jbc.M111.264739. Epub 2011 Jul 5. J Biol Chem. 2011. PMID: 21730071 Free PMC article.

5

Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.

Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz Á, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV. Grimster NP, et al. Among authors: ho ky. J Am Chem Soc. 2012 Apr 18;134(15):6732-40. doi: 10.1021/ja3001858. Epub 2012 Apr 6. J Am Chem Soc. 2012. PMID: 22394239 Free PMC article.

6

Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.

Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, Taylor P. Yamauchi JG, et al. Among authors: ho ky. Mol Pharmacol. 2012 Oct;82(4):687-99. doi: 10.1124/mol.112.080291. Epub 2012 Jul 11. Mol Pharmacol. 2012. PMID: 22784805 Free PMC article.

7

A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.

Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radić Z. Gerlits O, et al. Among authors: ho ky. Chem Biol Interact. 2019 Aug 25;309:108698. doi: 10.1016/j.cbi.2019.06.011. Epub 2019 Jun 7. Chem Biol Interact. 2019. PMID: 31176713 Free PMC article.

8

Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical.

Taylor P, Shyong YJ, Samskey N, Ho KY, Radic' Z, Fenical W, Sharpless KB, Kovarik Z, Camacho-Hernandez GA. Taylor P, et al. Among authors: ho ky. J Neurochem. 2021 Sep;158(6):1217-1222. doi: 10.1111/jnc.15335. Epub 2021 Mar 12. J Neurochem. 2021. PMID: 33638151 Free article. Review.

9

A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides.

Rosenberg YJ, Garcia K, Diener J, Sullivan D, Donahue S, Mao L, Lees J, Jiang X, Urban LA, Momper JD, Ho KY, Taylor P. Rosenberg YJ, et al. Among authors: ho ky. J Neurochem. 2024 Apr;168(4):370-380. doi: 10.1111/jnc.15777. Epub 2023 Apr 6. J Neurochem. 2024. PMID: 36786545

10

Virtual screening against acetylcholine binding protein.

Utsintong M, Rojsanga P, Ho KY, Talley TT, Olson AJ, Matsumoto K, Vajragupta O. Utsintong M, et al. Among authors: ho ky. J Biomol Screen. 2012 Feb;17(2):204-15. doi: 10.1177/1087057111421667. Epub 2011 Sep 28. J Biomol Screen. 2012. PMID: 21956172 Free PMC article.

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