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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells.
Méndez-Mancilla A, Wessels HH, Legut M, Kadina A, Mabuchi M, Walker J, Robb GB, Holden K, Sanjana NE. Méndez-Mancilla A, et al. Among authors: kadina a. Cell Chem Biol. 2022 Feb 17;29(2):321-327.e4. doi: 10.1016/j.chembiol.2021.07.011. Epub 2021 Aug 2. Cell Chem Biol. 2022. PMID: 34343484 Free PMC article.
CRISPRoff enables spatio-temporal control of CRISPR editing.
Carlson-Stevermer J, Kelso R, Kadina A, Joshi S, Rossi N, Walker J, Stoner R, Maures T. Carlson-Stevermer J, et al. Among authors: kadina a. Nat Commun. 2020 Oct 7;11(1):5041. doi: 10.1038/s41467-020-18853-3. Nat Commun. 2020. PMID: 33028827 Free PMC article.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: kadina ap. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.
Zeng L, Liu Y, Nguyenla XH, Abbott TR, Han M, Zhu Y, Chemparathy A, Lin X, Chen X, Wang H, Rane DA, Spatz JM, Jain S, Rustagi A, Pinsky B, Zepeda AE, Kadina AP, Walker JA 3rd, Holden K, Temperton N, Cochran JR, Barron AE, Connolly MD, Blish CA, Lewis DB, Stanley SA, La Russa MF, Qi LS. Zeng L, et al. Among authors: kadina ap. Nat Commun. 2022 May 19;13(1):2766. doi: 10.1038/s41467-022-30546-7. Nat Commun. 2022. PMID: 35589813 Free PMC article.
RNA Cloaking by Reversible Acylation.
Kadina A, Kietrys AM, Kool ET. Kadina A, et al. Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3059-3063. doi: 10.1002/anie.201708696. Epub 2018 Feb 22. Angew Chem Int Ed Engl. 2018. PMID: 29370460 Free PMC article.
Trapping Transient RNA Complexes by Chemically Reversible Acylation.
Velema WA, Park HS, Kadina A, Orbai L, Kool ET. Velema WA, et al. Among authors: kadina a. Angew Chem Int Ed Engl. 2020 Dec 1;59(49):22017-22022. doi: 10.1002/anie.202010861. Epub 2020 Sep 28. Angew Chem Int Ed Engl. 2020. PMID: 32845055 Free PMC article.
15 results