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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Hellwig CT, Delgado ME, Skoko J, Dyck L, Hanna C, Wentges A, Langlais C, Hagenlocher C, Mack A, Dinsdale D, Cain K, MacFarlane M, Rehm M. Hellwig CT, et al. Among authors: dyck l. Cell Death Differ. 2022 Jan;29(1):147-155. doi: 10.1038/s41418-021-00843-7. Epub 2021 Aug 5. Cell Death Differ. 2022. PMID: 34354257 Free PMC article.
Srebp-controlled glucose metabolism is essential for NK cell functional responses.
Assmann N, O'Brien KL, Donnelly RP, Dyck L, Zaiatz-Bittencourt V, Loftus RM, Heinrich P, Oefner PJ, Lynch L, Gardiner CM, Dettmer K, Finlay DK. Assmann N, et al. Among authors: dyck l. Nat Immunol. 2017 Nov;18(11):1197-1206. doi: 10.1038/ni.3838. Epub 2017 Sep 18. Nat Immunol. 2017. PMID: 28920951
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells.
Galvin KC, Dyck L, Marshall NA, Stefanska AM, Walsh KP, Moran B, Higgins SC, Dungan LS, Mills KH. Galvin KC, et al. Among authors: dyck l. Cancer Immunol Immunother. 2013 Jul;62(7):1273-82. doi: 10.1007/s00262-013-1432-8. Epub 2013 May 9. Cancer Immunol Immunother. 2013. PMID: 23657628 Free PMC article.
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses.
Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Michelet X, et al. Among authors: dyck l. Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7. Epub 2018 Nov 12. Nat Immunol. 2018. PMID: 30420624
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.
Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Lopes N, et al. Among authors: dyck l. Nat Immunol. 2021 Feb;22(2):179-192. doi: 10.1038/s41590-020-00848-3. Epub 2021 Jan 18. Nat Immunol. 2021. PMID: 33462452 Free PMC article.
159 results