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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Hellwig CT, Delgado ME, Skoko J, Dyck L, Hanna C, Wentges A, Langlais C, Hagenlocher C, Mack A, Dinsdale D, Cain K, MacFarlane M, Rehm M. Hellwig CT, et al. Among authors: wentges a. Cell Death Differ. 2022 Jan;29(1):147-155. doi: 10.1038/s41418-021-00843-7. Epub 2021 Aug 5. Cell Death Differ. 2022. PMID: 34354257 Free PMC article.