Kokot M - Search Results

1

A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs.

Kolarič A, Kokot M, Hrast M, Weiss M, Zdovc I, Trontelj J, Žakelj S, Anderluh M, Minovski N. Kolarič A, et al. Among authors: kokot m. Antibiotics (Basel). 2021 Jul 15;10(7):862. doi: 10.3390/antibiotics10070862. Antibiotics (Basel). 2021. PMID: 34356782 Free PMC article.

2

Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity.

Kokot M, Weiss M, Zdovc I, Hrast M, Anderluh M, Minovski N. Kokot M, et al. ACS Med Chem Lett. 2021 Aug 16;12(9):1478-1485. doi: 10.1021/acsmedchemlett.1c00345. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34527181 Free PMC article.

3

The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.

Kokot M, Anderluh M, Hrast M, Minovski N. Kokot M, et al. J Med Chem. 2022 May 12;65(9):6431-6440. doi: 10.1021/acs.jmedchem.2c00039. Epub 2022 May 3. J Med Chem. 2022. PMID: 35503563 Free PMC article. Review.

4

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.

Kokot M, Weiss M, Zdovc I, Anderluh M, Hrast M, Minovski N. Kokot M, et al. Bioorg Chem. 2022 Nov;128:106087. doi: 10.1016/j.bioorg.2022.106087. Epub 2022 Aug 11. Bioorg Chem. 2022. PMID: 35970069

5

Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.

Kokot M, Weiss M, Zdovc I, Senerovic L, Radakovic N, Anderluh M, Minovski N, Hrast M. Kokot M, et al. Eur J Med Chem. 2023 Mar 15;250:115160. doi: 10.1016/j.ejmech.2023.115160. Epub 2023 Feb 2. Eur J Med Chem. 2023. PMID: 36753879 Free article.

6

Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions.

Kokot M, Novak D, Zdovc I, Anderluh M, Hrast M, Minovski N. Kokot M, et al. Antibiotics (Basel). 2023 May 18;12(5):930. doi: 10.3390/antibiotics12050930. Antibiotics (Basel). 2023. PMID: 37237833 Free PMC article.

7

The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials.

Zorman M, Hrast Rambaher M, Kokot M, Minovski N, Anderluh M. Zorman M, et al. Among authors: kokot m. Eur J Pharm Sci. 2024 Jan 1;192:106632. doi: 10.1016/j.ejps.2023.106632. Epub 2023 Nov 9. Eur J Pharm Sci. 2024. PMID: 37949194 Free article. Review.

8

Dynamic Profiling and Binding Affinity Prediction of NBTI Antibacterials against DNA Gyrase Enzyme by Multidimensional Machine Learning and Molecular Dynamics Simulations.

Kokot M, Minovski N. Kokot M, et al. ACS Omega. 2024 Apr 11;9(16):18278-18295. doi: 10.1021/acsomega.4c00036. eCollection 2024 Apr 23. ACS Omega. 2024. PMID: 38680300 Free PMC article.

9

Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria.

Zorman M, Kokot M, Zdovc I, Senerovic L, Mandic M, Zidar N, Cotman AE, Durcik M, Peterlin Mašič L, Minovski N, Anderluh M, Hrast Rambaher M. Zorman M, et al. Among authors: kokot m. Antibiotics (Basel). 2024 Nov 13;13(11):1081. doi: 10.3390/antibiotics13111081. Antibiotics (Basel). 2024. PMID: 39596774 Free PMC article.

10

Structural Aspects of Mycobacterium tuberculosis DNA Gyrase Targeted by Novel Bacterial Topoisomerase Inhibitors.

Kokot M, Hrast Rambaher M, Feng L, Mitchenall LA, Lawson DM, Maxwell A, Parish T, Minovski N, Anderluh M. Kokot M, et al. ACS Med Chem Lett. 2024 Nov 22;15(12):2164-2170. doi: 10.1021/acsmedchemlett.4c00447. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691510 Free PMC article.

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