Minovski N - Search Results

1

A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs.

Kolarič A, Kokot M, Hrast M, Weiss M, Zdovc I, Trontelj J, Žakelj S, Anderluh M, Minovski N. Kolarič A, et al. Among authors: minovski n. Antibiotics (Basel). 2021 Jul 15;10(7):862. doi: 10.3390/antibiotics10070862. Antibiotics (Basel). 2021. PMID: 34356782 Free PMC article.

2

Structure-based design of novel combinatorially generated NBTIs as potential DNA gyrase inhibitors against various Staphylococcus aureus mutant strains.

Kolaric A, Minovski N. Kolaric A, et al. Among authors: minovski n. Mol Biosyst. 2017 Jun 27;13(7):1406-1420. doi: 10.1039/c7mb00168a. Mol Biosyst. 2017. PMID: 28590495

3

Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators.

Kolarič A, Švajger U, Tomašič T, Brox R, Frank T, Minovski N, Tschammer N, Anderluh M. Kolarič A, et al. Among authors: minovski n. Eur J Med Chem. 2018 Jun 25;154:68-90. doi: 10.1016/j.ejmech.2018.05.013. Epub 2018 May 11. Eur J Med Chem. 2018. PMID: 29777988

4

Novel bacterial topoisomerase inhibitors: challenges and perspectives in reducing hERG toxicity.

Kolarič A, Minovski N. Kolarič A, et al. Among authors: minovski n. Future Med Chem. 2018 Oct 1;10(19):2241-2244. doi: 10.4155/fmc-2018-0272. Epub 2018 Sep 14. Future Med Chem. 2018. PMID: 30215281 No abstract available.

5

Cyclohexyl amide-based novel bacterial topoisomerase inhibitors with prospective GyrA-binding fragments.

Kolarič A, Novak D, Weiss M, Hrast M, Zdovc I, Anderluh M, Minovski N. Kolarič A, et al. Among authors: minovski n. Future Med Chem. 2019 May;11(9):935-945. doi: 10.4155/fmc-2018-0472. Epub 2019 May 29. Future Med Chem. 2019. PMID: 31140866

6

Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs).

Kolarič A, Anderluh M, Minovski N. Kolarič A, et al. Among authors: minovski n. J Med Chem. 2020 Jun 11;63(11):5664-5674. doi: 10.1021/acs.jmedchem.9b01738. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32027491 Free PMC article. Review.

7

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.

Kolarič A, Germe T, Hrast M, Stevenson CEM, Lawson DM, Burton NP, Vörös J, Maxwell A, Minovski N, Anderluh M. Kolarič A, et al. Among authors: minovski n. Nat Commun. 2021 Jan 8;12(1):150. doi: 10.1038/s41467-020-20405-8. Nat Commun. 2021. PMID: 33420011 Free PMC article.

8

Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity.

Kokot M, Weiss M, Zdovc I, Hrast M, Anderluh M, Minovski N. Kokot M, et al. Among authors: minovski n. ACS Med Chem Lett. 2021 Aug 16;12(9):1478-1485. doi: 10.1021/acsmedchemlett.1c00345. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34527181 Free PMC article.

9

The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.

Kokot M, Anderluh M, Hrast M, Minovski N. Kokot M, et al. Among authors: minovski n. J Med Chem. 2022 May 12;65(9):6431-6440. doi: 10.1021/acs.jmedchem.2c00039. Epub 2022 May 3. J Med Chem. 2022. PMID: 35503563 Free PMC article. Review.

10

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.

Kokot M, Weiss M, Zdovc I, Anderluh M, Hrast M, Minovski N. Kokot M, et al. Among authors: minovski n. Bioorg Chem. 2022 Nov;128:106087. doi: 10.1016/j.bioorg.2022.106087. Epub 2022 Aug 11. Bioorg Chem. 2022. PMID: 35970069

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