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Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Bellenie BR, Hall E, Bruce I, Spendiff M, Culshaw A, McDonald S, Ambarkhane A, Chinn C, Thomas M, Rosner E, Bracher M, Nicklin P, Marshall S, Coote J, Cullen E, Tessier C, Wuersch K, Lal A, Wallis G, Hollingworth GJ, Neef J. Bellenie BR, et al. Among authors: ambarkhane a. J Med Chem. 2021 Aug 26;64(16):12304-12321. doi: 10.1021/acs.jmedchem.1c00986. Epub 2021 Aug 12. J Med Chem. 2021. PMID: 34384024