Leonard TA - Search Results

1

Structure of autoinhibited Akt1 reveals mechanism of PIP₃-mediated activation.

Truebestein L, Hornegger H, Anrather D, Hartl M, Fleming KD, Stariha JTB, Pardon E, Steyaert J, Burke JE, Leonard TA. Truebestein L, et al. Among authors: leonard ta. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2101496118. doi: 10.1073/pnas.2101496118. Proc Natl Acad Sci U S A. 2021. PMID: 34385319 Free PMC article.

2

Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture.

Lučić I, Truebestein L, Leonard TA. Lučić I, et al. Among authors: leonard ta. J Mol Biol. 2016 Jan 16;428(1):121-141. doi: 10.1016/j.jmb.2015.11.001. Epub 2015 Nov 12. J Mol Biol. 2016. PMID: 26582574

3

A molecular ruler regulates cytoskeletal remodelling by the Rho kinases.

Truebestein L, Elsner DJ, Fuchs E, Leonard TA. Truebestein L, et al. Among authors: leonard ta. Nat Commun. 2015 Dec 1;6:10029. doi: 10.1038/ncomms10029. Nat Commun. 2015. PMID: 26620183 Free PMC article.

4

Made to measure - keeping Rho kinase at a distance.

Truebestein L, Elsner DJ, Leonard TA. Truebestein L, et al. Among authors: leonard ta. Small GTPases. 2016 Apr 2;7(2):82-92. doi: 10.1080/21541248.2016.1173770. Epub 2016 Apr 12. Small GTPases. 2016. PMID: 27070834 Free PMC article. Review.

5

Coiled-coils: The long and short of it.

Truebestein L, Leonard TA. Truebestein L, et al. Among authors: leonard ta. Bioessays. 2016 Sep;38(9):903-16. doi: 10.1002/bies.201600062. Epub 2016 Aug 5. Bioessays. 2016. PMID: 27492088 Free PMC article. Review.

6

PI(3,4,5)P₃ Engagement Restricts Akt Activity to Cellular Membranes.

Ebner M, Lučić I, Leonard TA, Yudushkin I. Ebner M, et al. Among authors: leonard ta. Mol Cell. 2017 Feb 2;65(3):416-431.e6. doi: 10.1016/j.molcel.2016.12.028. Mol Cell. 2017. PMID: 28157504 Free article.

7

Conformational sampling of membranes by Akt controls its activation and inactivation.

Lučić I, Rathinaswamy MK, Truebestein L, Hamelin DJ, Burke JE, Leonard TA. Lučić I, et al. Among authors: leonard ta. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3940-E3949. doi: 10.1073/pnas.1716109115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632185 Free PMC article.

8

Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.

Leonard TA. Leonard TA. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6101-E6102. doi: 10.1073/pnas.1808882115. Epub 2018 Jun 15. Proc Natl Acad Sci U S A. 2018. PMID: 29907610 Free PMC article. No abstract available.

9

Lipid-dependent Akt-ivity: where, when, and how.

Siess KM, Leonard TA. Siess KM, et al. Among authors: leonard ta. Biochem Soc Trans. 2019 Jun 28;47(3):897-908. doi: 10.1042/BST20190013. Epub 2019 May 30. Biochem Soc Trans. 2019. PMID: 31147387 Free PMC article. Review.

10

A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation.

Elsner DJ, Siess KM, Gossenreiter T, Hartl M, Leonard TA. Elsner DJ, et al. Among authors: leonard ta. J Biol Chem. 2019 Sep 27;294(39):14422-14441. doi: 10.1074/jbc.RA119.008713. Epub 2019 Aug 12. J Biol Chem. 2019. PMID: 31406020 Free PMC article.

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