Fu W - Search Results

1

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. He Q, et al. Among authors: fu w. J Med Chem. 2021 Aug 26;64(16):12414-12433. doi: 10.1021/acs.jmedchem.1c01082. Epub 2021 Aug 13. J Med Chem. 2021. PMID: 34387468

2

Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.

Xie Q, Wang H, Xia Z, Lu M, Zhang W, Wang X, Fu W, Tang Y, Sheng W, Li W, Zhou W, Zhu X, Qiu Z, Chen H. Xie Q, et al. Among authors: fu w. J Med Chem. 2008 Apr 10;51(7):2027-36. doi: 10.1021/jm070154q. Epub 2008 Mar 12. J Med Chem. 2008. PMID: 18333606

3

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL. Paz A, et al. Among authors: fu w. J Med Chem. 2009 Apr 23;52(8):2543-9. doi: 10.1021/jm801657v. J Med Chem. 2009. PMID: 19326912

4

Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Li W, Tao YM, Tang Y, Xu XJ, Chen J, Fu W, Wang XH, Chao B, Sheng W, Xie Q, Qiu ZB, Liu JG. Li W, et al. Among authors: fu w. Bioorg Med Chem Lett. 2010 Jan 1;20(1):418-21. doi: 10.1016/j.bmcl.2009.07.119. Epub 2009 Jul 29. Bioorg Med Chem Lett. 2010. PMID: 19932964

5

Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.

Ma K, Wang P, Fu W, Wan X, Zhou L, Chu Y, Ye D. Ma K, et al. Among authors: fu w. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6724-7. doi: 10.1016/j.bmcl.2011.09.054. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21996518

6

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives.

Fu W, Wang J, Yu L, Zhao L, Lu N, You Q, Guo Q, Li Z. Fu W, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1118-21. doi: 10.1016/j.bmcl.2011.11.117. Epub 2011 Dec 6. Bioorg Med Chem Lett. 2012. PMID: 22196122

7

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

Li B, Li W, Du P, Yu KQ, Fu W. Li B, et al. Among authors: fu w. J Phys Chem B. 2012 Jul 19;116(28):8121-30. doi: 10.1021/jp3049235. Epub 2012 Jul 3. J Phys Chem B. 2012. PMID: 22702398

8

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.

Xu G, Lv B, Roberge JY, Xu B, Du J, Dong J, Chen Y, Peng K, Zhang L, Tang X, Feng Y, Xu M, Fu W, Zhang W, Zhu L, Deng Z, Sheng Z, Welihinda A, Sun X. Xu G, et al. Among authors: fu w. J Med Chem. 2014 Feb 27;57(4):1236-51. doi: 10.1021/jm401780b. Epub 2014 Feb 12. J Med Chem. 2014. PMID: 24456245

9

A computational perspective on drug discovery and signal transduction mechanism of dopamine and serotonin receptors in the treatment of schizophrenia.

Lian P, Xu L, Geng C, Qian Y, Li W, Zhen X, Fu W. Lian P, et al. Among authors: fu w. Curr Pharm Biotechnol. 2014;15(10):916-26. doi: 10.2174/1389201015666140909150033. Curr Pharm Biotechnol. 2014. PMID: 25213308 Review.

10

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands.

Shen Q, Qian YY, Xu XJ, Li W, Liu JG, Fu W. Shen Q, et al. Among authors: fu w. Acta Pharmacol Sin. 2015 Jul;36(7):887-94. doi: 10.1038/aps.2014.171. Epub 2015 Jun 8. Acta Pharmacol Sin. 2015. PMID: 26051109 Free PMC article.

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