Henze DA - Search Results

1

Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey.

Lange HS, Vardigan JD, Cannon CE, Puri V, Henze DA, Uslaner JM. Lange HS, et al. Among authors: henze da. Neuropharmacology. 2021 Oct 1;197:108754. doi: 10.1016/j.neuropharm.2021.108754. Epub 2021 Aug 11. Neuropharmacology. 2021. PMID: 34389398

2

Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.

Vardigan JD, Houghton AK, Lange HS, Adarayan ED, Pall PS, Ballard JE, Henze DA, Uslaner JM. Vardigan JD, et al. Among authors: henze da. J Pain Res. 2018 Apr 11;11:735-741. doi: 10.2147/JPR.S152879. eCollection 2018. J Pain Res. 2018. PMID: 29692626 Free PMC article.

3

Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate.

Ballard JE, Pall P, Vardigan J, Zhao F, Holahan MA, Kraus R, Li Y, Henze D, Houghton A, Burgey CS, Gibson C. Ballard JE, et al. Pharm Res. 2020 Sep 4;37(10):181. doi: 10.1007/s11095-020-02914-9. Pharm Res. 2020. PMID: 32888082 Free PMC article.

4

Na_v1.7 target modulation and efficacy can be measured in nonhuman primate assays.

Kraus RL, Zhao F, Pall PS, Zhou D, Vardigan JD, Danziger A, Li Y, Daley C, Ballard JE, Clements MK, Klein RM, Holahan MA, Greshock TJ, Kim RM, Layton ME, Burgey CS, Serra J, Henze DA, Houghton AK. Kraus RL, et al. Among authors: henze da. Sci Transl Med. 2021 May 19;13(594):eaay1050. doi: 10.1126/scitranslmed.aay1050. Sci Transl Med. 2021. PMID: 34011626

5

Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose.

Ballard JE, Pall PS, Vardigan J, Zhao F, Holahan MA, Zhou X, Jochnowitz N, Kraus RL, Klein RM, Henze DA, Houghton AK, Burgey CS, Gibson C, Struyk A. Ballard JE, et al. Among authors: henze da. Front Pharmacol. 2021 Dec 24;12:786078. doi: 10.3389/fphar.2021.786078. eCollection 2021. Front Pharmacol. 2021. PMID: 35002718 Free PMC article.

6

Antinociceptive effects of potent, selective and brain penetrant muscarinic M₄ positive allosteric modulators in rodent pain models.

Grauer SM, Sanoja R, Poulin D, Rashid H, Jochnowitz N, Calhoun M, Zwilling D, Varty GB, Rosahl TW, Meziane H, Mittlelhaeuser C, Mazzola R, Morrow J, Smith SM, Henze D, Marcus J. Grauer SM, et al. Brain Res. 2020 Jun 15;1737:146814. doi: 10.1016/j.brainres.2020.146814. Epub 2020 Mar 29. Brain Res. 2020. PMID: 32234514

7

The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.

Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG. Catalano SM, et al. Among authors: henze da. Curr Top Med Chem. 2006;6(6):597-608. doi: 10.2174/156802606776743066. Curr Top Med Chem. 2006. PMID: 16712494 Review.

8

Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.

Price EA, Krasowska-Zoladek A, Nanda KK, Stachel SJ, Henze DA. Price EA, et al. Among authors: henze da. J Neurosci Methods. 2017 Apr 15;282:34-42. doi: 10.1016/j.jneumeth.2017.03.001. Epub 2017 Mar 7. J Neurosci Methods. 2017. PMID: 28279735

9

Challenges faced in choosing novel targets to treat chronic pain.

Henze DA. Henze DA. Future Med Chem. 2009 May;1(2):231-5. doi: 10.4155/fmc.09.33. Future Med Chem. 2009. PMID: 21425964 No abstract available.

10

Benzoxazolinone aryl sulfonamides as potent, selective Na_v1.7 inhibitors with in vivo efficacy in a preclinical pain model.

Pero JE, Rossi MA, Lehman HDGF, Kelly MJ 3rd, Mulhearn JJ, Wolkenberg SE, Cato MJ, Clements MK, Daley CJ, Filzen T, Finger EN, Gregan Y, Henze DA, Jovanovska A, Klein R, Kraus RL, Li Y, Liang A, Majercak JM, Panigel J, Urban MO, Wang J, Wang YH, Houghton AK, Layton ME. Pero JE, et al. Among authors: henze da. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2683-2688. doi: 10.1016/j.bmcl.2017.04.040. Epub 2017 Apr 22. Bioorg Med Chem Lett. 2017. PMID: 28465103

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