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RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C. Nilsson KH, et al. Among authors: koskela a. Nat Commun. 2021 Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. Nat Commun. 2021. PMID: 34389713 Free PMC article.
Estrogen receptor-α expression in neuronal cells affects bone mass.
Ohlsson C, Engdahl C, Börjesson AE, Windahl SH, Studer E, Westberg L, Eriksson E, Koskela A, Tuukkanen J, Krust A, Chambon P, Carlsten H, Lagerquist MK. Ohlsson C, et al. Among authors: koskela a. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):983-8. doi: 10.1073/pnas.1111436109. Epub 2012 Jan 3. Proc Natl Acad Sci U S A. 2012. PMID: 22215598 Free PMC article.
The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators in male mice.
Börjesson AE, Farman HH, Engdahl C, Koskela A, Sjögren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, Ohlsson C. Börjesson AE, et al. Among authors: koskela a. J Bone Miner Res. 2013 May;28(5):1117-26. doi: 10.1002/jbmr.1842. J Bone Miner Res. 2013. PMID: 23225083 Free PMC article.
Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.
Windahl SH, Börjesson AE, Farman HH, Engdahl C, Movérare-Skrtic S, Sjögren K, Lagerquist MK, Kindblom JM, Koskela A, Tuukkanen J, Divieti Pajevic P, Feng JQ, Dahlman-Wright K, Antonson P, Gustafsson JÅ, Ohlsson C. Windahl SH, et al. Among authors: koskela a. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2294-9. doi: 10.1073/pnas.1220811110. Epub 2013 Jan 23. Proc Natl Acad Sci U S A. 2013. PMID: 23345419 Free PMC article.
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C. Movérare-Skrtic S, et al. Among authors: koskela a. Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12. Nat Med. 2014. PMID: 25306233 Free PMC article.
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