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RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C. Nilsson KH, et al. Among authors: wu j. Nat Commun. 2021 Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. Nat Commun. 2021. PMID: 34389713 Free PMC article.
The bone-sparing effects of estrogen and WNT16 are independent of each other.
Movérare-Skrtic S, Wu J, Henning P, Gustafsson KL, Sjögren K, Windahl SH, Koskela A, Tuukkanen J, Börjesson AE, Lagerquist MK, Lerner UH, Zhang FP, Gustafsson JÅ, Poutanen M, Ohlsson C. Movérare-Skrtic S, et al. Among authors: wu j. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14972-7. doi: 10.1073/pnas.1520408112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26627248 Free PMC article.
Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1.
Farman HH, Wu J, Gustafsson KL, Windahl SH, Kim SH, Katzenellenbogen JA, Ohlsson C, Lagerquist MK. Farman HH, et al. Among authors: wu j. J Mol Endocrinol. 2017 Feb;58(2):105-111. doi: 10.1530/JME-16-0209. Epub 2017 Jan 5. J Mol Endocrinol. 2017. PMID: 28057769 Free PMC article.
Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
Jansson JO, Palsdottir V, Hägg DA, Schéle E, Dickson SL, Anesten F, Bake T, Montelius M, Bellman J, Johansson ME, Cone RD, Drucker DJ, Wu J, Aleksic B, Törnqvist AE, Sjögren K, Gustafsson JÅ, Windahl SH, Ohlsson C. Jansson JO, et al. Among authors: wu j. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):427-432. doi: 10.1073/pnas.1715687114. Epub 2017 Dec 26. Proc Natl Acad Sci U S A. 2018. PMID: 29279372 Free PMC article.
WNT16 overexpression partly protects against glucocorticoid-induced bone loss.
Ohlsson C, Nilsson KH, Henning P, Wu J, Gustafsson KL, Poutanen M, Lerner UH, Movérare-Skrtic S. Ohlsson C, et al. Among authors: wu j. Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E597-E604. doi: 10.1152/ajpendo.00292.2017. Epub 2018 Feb 6. Am J Physiol Endocrinol Metab. 2018. PMID: 29406783 Free article.
Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice.
Ohlsson C, Henning P, Nilsson KH, Wu J, Gustafsson KL, Sjögren K, Törnqvist A, Koskela A, Zhang FP, Lagerquist MK, Poutanen M, Tuukkanen J, Lerner UH, Movérare-Skrtic S. Ohlsson C, et al. Among authors: wu j. J Endocrinol. 2018 May;237(2):113-122. doi: 10.1530/JOE-18-0020. Epub 2018 Mar 12. J Endocrinol. 2018. PMID: 29530924 Free PMC article.
ERα expression in T lymphocytes is dispensable for estrogenic effects in bone.
Gustafsson KL, Nilsson KH, Farman HH, Andersson A, Lionikaite V, Henning P, Wu J, Windahl SH, Islander U, Movérare-Skrtic S, Sjögren K, Carlsten H, Gustafsson JÅ, Ohlsson C, Lagerquist MK. Gustafsson KL, et al. Among authors: wu j. J Endocrinol. 2018 Aug;238(2):129-136. doi: 10.1530/JOE-18-0183. Epub 2018 May 30. J Endocrinol. 2018. PMID: 29848607 Free PMC article.
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