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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma.
Lewis CS, Karve A, Matiash K, Stone T, Li J, Wang JK, Versteeg HH, Aronow BJ, Ahmad SA, Desai PB, Bogdanov VY. Lewis CS, et al. Among authors: versteeg hh. Front Oncol. 2021 Jul 29;11:691685. doi: 10.3389/fonc.2021.691685. eCollection 2021. Front Oncol. 2021. PMID: 34395257 Free PMC article.
Alternatively spliced tissue factor induces angiogenesis through integrin ligation.
van den Berg YW, van den Hengel LG, Myers HR, Ayachi O, Jordanova E, Ruf W, Spek CA, Reitsma PH, Bogdanov VY, Versteeg HH. van den Berg YW, et al. Among authors: versteeg hh. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19497-502. doi: 10.1073/pnas.0905325106. Epub 2009 Oct 29. Proc Natl Acad Sci U S A. 2009. PMID: 19875693 Free PMC article.
Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling.
Srinivasan R, Ozhegov E, van den Berg YW, Aronow BJ, Franco RS, Palascak MB, Fallon JT, Ruf W, Versteeg HH, Bogdanov VY. Srinivasan R, et al. Among authors: versteeg hh. J Thromb Haemost. 2011 Oct;9(10):2087-96. doi: 10.1111/j.1538-7836.2011.04454.x. J Thromb Haemost. 2011. PMID: 21812913 Free PMC article.
Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.
Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY. Unruh D, et al. Among authors: versteeg hh. Int J Cancer. 2014 Jan 1;134(1):9-20. doi: 10.1002/ijc.28327. Epub 2013 Jul 27. Int J Cancer. 2014. PMID: 23754313 Free PMC article.
Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner.
Kocatürk B, Van den Berg YW, Tieken C, Mieog JS, de Kruijf EM, Engels CC, van der Ent MA, Kuppen PJ, Van de Velde CJ, Ruf W, Reitsma PH, Osanto S, Liefers GJ, Bogdanov VY, Versteeg HH. Kocatürk B, et al. Among authors: versteeg hh. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11517-22. doi: 10.1073/pnas.1307100110. Epub 2013 Jun 25. Proc Natl Acad Sci U S A. 2013. PMID: 23801760 Free PMC article.
Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma.
Unruh D, Ünlü B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY. Unruh D, et al. Among authors: versteeg hh. Oncotarget. 2016 May 3;7(18):25264-75. doi: 10.18632/oncotarget.7955. Oncotarget. 2016. PMID: 26967388 Free PMC article.
156 results