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Page 1
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Emin D, Zhang YP, Lobanova E, Miller A, Li X, Xia Z, Dakin H, Sideris DI, Lam JYL, Ranasinghe RT, Kouli A, Zhao Y, De S, Knowles TPJ, Vendruscolo M, Ruggeri FS, Aigbirhio FI, Williams-Gray CH, Klenerman D. Emin D, et al. Among authors: lam jyl. Nat Commun. 2022 Sep 20;13(1):5512. doi: 10.1038/s41467-022-33252-6. Nat Commun. 2022. PMID: 36127374 Free PMC article.
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D. Dimou E, et al. Among authors: lam jyl. Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1. Cell Rep. 2023. PMID: 37393617 Free PMC article.
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.
Fertan E, Böken D, Murray A, Danial JSH, Lam JYL, Wu Y, Goh PA, Alić I, Cheetham MR, Lobanova E, Zhang YP, Nižetić D, Klenerman D. Fertan E, et al. Among authors: lam jyl. Mol Psychiatry. 2024 Feb;29(2):369-386. doi: 10.1038/s41380-023-02333-3. Epub 2023 Dec 15. Mol Psychiatry. 2024. PMID: 38102482 Free PMC article.
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM, Dimou E, Hidari E, Zhang YP, Lam JYL, Danial JSH, Strickland MR, Jiang H, Thornton P, Crowther DC, Ohtonen S, Gómez-Budia M, Bell SM, Ferraiuolo L, Mortiboys H, Higginbottom A, Wharton SB, Holtzman DM, Malm T, Ranasinghe RT, Klenerman D, De S. Xia Z, et al. Among authors: lam jyl. Nat Commun. 2024 Jun 1;15(1):4695. doi: 10.1038/s41467-024-49028-z. Nat Commun. 2024. PMID: 38824138 Free PMC article.
12 results