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Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.
Sideris DI, Danial JSH, Emin D, Ruggeri FS, Xia Z, Zhang YP, Lobanova E, Dakin H, De S, Miller A, Sang JC, Knowles TPJ, Vendruscolo M, Fraser G, Crowther D, Klenerman D. Sideris DI, et al. Among authors: zhang yp. Brain Commun. 2021 Jul 2;3(3):fcab147. doi: 10.1093/braincomms/fcab147. eCollection 2021. Brain Commun. 2021. PMID: 34396107 Free PMC article.
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Emin D, Zhang YP, Lobanova E, Miller A, Li X, Xia Z, Dakin H, Sideris DI, Lam JYL, Ranasinghe RT, Kouli A, Zhao Y, De S, Knowles TPJ, Vendruscolo M, Ruggeri FS, Aigbirhio FI, Williams-Gray CH, Klenerman D. Emin D, et al. Among authors: zhang yp. Nat Commun. 2022 Sep 20;13(1):5512. doi: 10.1038/s41467-022-33252-6. Nat Commun. 2022. PMID: 36127374 Free PMC article.
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.
Kulenkampff K, Emin D, Staats R, Zhang YP, Sakhnini L, Kouli A, Rimon O, Lobanova E, Williams-Gray CH, Aprile FA, Sormanni P, Klenerman D, Vendruscolo M. Kulenkampff K, et al. Among authors: zhang yp. Chem Sci. 2022 Sep 22;13(46):13815-13828. doi: 10.1039/d2sc00066k. eCollection 2022 Nov 30. Chem Sci. 2022. PMID: 36544716 Free PMC article.
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.
Fertan E, Böken D, Murray A, Danial JSH, Lam JYL, Wu Y, Goh PA, Alić I, Cheetham MR, Lobanova E, Zhang YP, Nižetić D, Klenerman D. Fertan E, et al. Among authors: zhang yp. Mol Psychiatry. 2024 Feb;29(2):369-386. doi: 10.1038/s41380-023-02333-3. Epub 2023 Dec 15. Mol Psychiatry. 2024. PMID: 38102482 Free PMC article.
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM, Dimou E, Hidari E, Zhang YP, Lam JYL, Danial JSH, Strickland MR, Jiang H, Thornton P, Crowther DC, Ohtonen S, Gómez-Budia M, Bell SM, Ferraiuolo L, Mortiboys H, Higginbottom A, Wharton SB, Holtzman DM, Malm T, Ranasinghe RT, Klenerman D, De S. Xia Z, et al. Among authors: zhang yp. Nat Commun. 2024 Jun 1;15(1):4695. doi: 10.1038/s41467-024-49028-z. Nat Commun. 2024. PMID: 38824138 Free PMC article.
2,192 results