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Page 1
Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics.
Akinci E, Cha M, Lin L, Yeo G, Hamilton MC, Donahue CJ, Bermudez-Cabrera HC, Zanetti LC, Chen M, Barkal SA, Khowpinitchai B, Chu N, Velimirovic M, Jodhani R, Fife JD, Sovrovic M, Cole PA, Davey RA, Cassa CA, Sherwood RI. Akinci E, et al. Among authors: barkal sa. bioRxiv [Preprint]. 2020 Aug 28:2020.08.27.270819. doi: 10.1101/2020.08.27.270819. bioRxiv. 2020. PMID: 32869031 Free PMC article. Preprint.
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. Barkal AA, et al. Among authors: barkal sa. Nature. 2019 Aug;572(7769):392-396. doi: 10.1038/s41586-019-1456-0. Epub 2019 Jul 31. Nature. 2019. PMID: 31367043 Free PMC article.
Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis.
Salahudeen AA, Seoane JA, Yuki K, Mah AT, Smith AR, Kolahi K, De la O SM, Hart DJ, Ding J, Ma Z, Barkal SA, Shukla ND, Zhang CH, Cantrell MA, Batish A, Usui T, Root DE, Hahn WC, Curtis C, Kuo CJ. Salahudeen AA, et al. Among authors: barkal sa. Cell Rep. 2023 Nov 28;42(11):113355. doi: 10.1016/j.celrep.2023.113355. Epub 2023 Nov 1. Cell Rep. 2023. PMID: 37922313 Free PMC article.
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L. Ryu J, et al. Among authors: barkal s. medRxiv [Preprint]. 2023 Sep 10:2023.09.08.23295253. doi: 10.1101/2023.09.08.23295253. medRxiv. 2023. Update in: Nat Genet. 2024 May;56(5):925-937. doi: 10.1038/s41588-024-01726-6 PMID: 37732177 Free PMC article. Updated. Preprint.
Systematic elucidation of genetic mechanisms underlying cholesterol uptake.
Hamilton MC, Fife JD, Akinci E, Yu T, Khowpinitchai B, Cha M, Barkal S, Thi TT, Yeo GHT, Ramos Barroso JP, Francoeur MJ, Velimirovic M, Gifford DK, Lettre G, Yu H, Cassa CA, Sherwood RI. Hamilton MC, et al. Among authors: barkal s. Cell Genom. 2023 Apr 21;3(5):100304. doi: 10.1016/j.xgen.2023.100304. eCollection 2023 May 10. Cell Genom. 2023. PMID: 37228746 Free PMC article.
A molecular glue approach to control the half-life of CRISPR-based technologies.
Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. Sreekanth V, et al. Among authors: barkal s. bioRxiv [Preprint]. 2023 Mar 20:2023.03.12.531757. doi: 10.1101/2023.03.12.531757. bioRxiv. 2023. PMID: 36945568 Free PMC article. Preprint.
Systematic elucidation of genetic mechanisms underlying cholesterol uptake.
Hamilton MC, Fife JD, Akinci E, Yu T, Khowpinitchai B, Cha M, Barkal S, Thi TT, Yeo GHT, Ramos Barroso JP, Jake Francoeur M, Velimirovic M, Gifford DK, Lettre G, Yu H, Cassa CA, Sherwood RI. Hamilton MC, et al. Among authors: barkal s. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.500804. doi: 10.1101/2023.01.09.500804. bioRxiv. 2023. Update in: Cell Genom. 2023 Apr 21;3(5):100304. doi: 10.1016/j.xgen.2023.100304 PMID: 36711952 Free PMC article. Updated. Preprint.