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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.
Lu G, Lomonosova E, Cheng X, Moran EA, Meyers MJ, Le Grice SF, Thomas CJ, Jiang JK, Meck C, Hirsch DR, D'Erasmo MP, Suyabatmaz DM, Murelli RP, Tavis JE. Lu G, et al. Among authors: tavis je. Antimicrob Agents Chemother. 2015 Feb;59(2):1070-9. doi: 10.1128/AAC.04617-14. Epub 2014 Dec 1. Antimicrob Agents Chemother. 2015. PMID: 25451058 Free PMC article.
The hepatitis B virus ribonuclease H as a drug target.
Tavis JE, Lomonosova E. Tavis JE, et al. Antiviral Res. 2015 Jun;118:132-8. doi: 10.1016/j.antiviral.2015.04.002. Epub 2015 Apr 8. Antiviral Res. 2015. PMID: 25862291 Free PMC article. Review.
Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice.
Long KR, Lomonosova E, Li Q, Ponzar NL, Villa JA, Touchette E, Rapp S, Liley RM, Murelli RP, Grigoryan A, Buller RM, Wilson L, Bial J, Sagartz JE, Tavis JE. Long KR, et al. Among authors: tavis je. Antiviral Res. 2018 Jan;149:41-47. doi: 10.1016/j.antiviral.2017.11.008. Epub 2017 Nov 10. Antiviral Res. 2018. PMID: 29129708 Free PMC article.
127 results