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Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling.
Protzek AO, Costa-Júnior JM, Rezende LF, Santos GJ, Araújo TG, Vettorazzi JF, Ortis F, Carneiro EM, Rafacho A, Boschero AC. Protzek AO, et al. Among authors: ortis f. Int J Endocrinol. 2014;2014:983453. doi: 10.1155/2014/983453. Epub 2014 Sep 17. Int J Endocrinol. 2014. PMID: 25313308 Free PMC article.
A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.
Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK. Fukaya M, et al. Among authors: ortis f. Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10. Mol Endocrinol. 2016. PMID: 26652732 Free PMC article.
ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process.
Ferreira SM, Costa-Júnior JM, Kurauti MA, Leite NC, Ortis F, Rezende LF, Barbosa HC, Boschero AC, Santos GJ. Ferreira SM, et al. Among authors: ortis f. Front Endocrinol (Lausanne). 2020 Nov 26;11:599165. doi: 10.3389/fendo.2020.599165. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33324349 Free PMC article.
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: ortis f. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
44 results