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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
Seixas JD, Sousa BB, Marques MC, Guerreiro A, Traquete R, Rodrigues T, Albuquerque IS, Sousa MFQ, Lemos AR, Sousa PMF, Bandeiras TM, Wu D, Doyle SK, Robinson CV, Koehler AN, Corzana F, Matias PM, Bernardes GJL. Seixas JD, et al. Among authors: koehler an. RSC Chem Biol. 2020 Aug 28;1(4):251-262. doi: 10.1039/d0cb00033g. eCollection 2020 Oct 1. RSC Chem Biol. 2020. PMID: 34458764 Free PMC article.
A Small-Molecule Inhibitor to the Cytokine Interleukin-4.
Quinnell SP, Leifer BS, Nestor ST, Tan K, Sheehy DF, Ceo L, Doyle SK, Koehler AN, Vegas AJ. Quinnell SP, et al. Among authors: koehler an. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654. doi: 10.1021/acschembio.0c00615. Epub 2020 Sep 16. ACS Chem Biol. 2020. PMID: 32902255
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
Richters A, Doyle SK, Freeman DB, Lee C, Leifer BS, Jagannathan S, Kabinger F, Koren JV, Struntz NB, Urgiles J, Stagg RA, Curtin BH, Chatterjee D, Mathea S, Mikochik PJ, Hopkins TD, Gao H, Branch JR, Xin H, Westover L, Bignan GC, Rupnow BA, Karlin KL, Olson CM, Westbrook TF, Vacca J, Wilfong CM, Trotter BW, Saffran DC, Bischofberger N, Knapp S, Russo JW, Hickson I, Bischoff JR, Gottardis MM, Balk SP, Lin CY, Pop MS, Koehler AN. Richters A, et al. Among authors: koehler an. Cell Chem Biol. 2021 Feb 18;28(2):134-147.e14. doi: 10.1016/j.chembiol.2020.10.001. Epub 2020 Oct 20. Cell Chem Biol. 2021. PMID: 33086052 Free article.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Among authors: koehler an. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M. de Waal L, et al. Among authors: koehler an. Nat Chem Biol. 2016 Feb;12(2):102-8. doi: 10.1038/nchembio.1984. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656089 Free PMC article.
Small-molecule microarrays as tools in ligand discovery.
Vegas AJ, Fuller JH, Koehler AN. Vegas AJ, et al. Among authors: koehler an. Chem Soc Rev. 2008 Jul;37(7):1385-94. doi: 10.1039/b703568n. Epub 2008 May 20. Chem Soc Rev. 2008. PMID: 18568164 Free PMC article. Review.
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.
Boskovic ZV, Kemp MM, Freedy AM, Viswanathan VS, Pop MS, Fuller JH, Martinez NM, Figueroa Lazú SO, Hong JA, Lewis TA, Calarese D, Love JD, Vetere A, Almo SC, Schreiber SL, Koehler AN. Boskovic ZV, et al. Among authors: koehler an. ACS Chem Biol. 2016 Jul 15;11(7):1844-51. doi: 10.1021/acschembio.6b00012. Epub 2016 Apr 29. ACS Chem Biol. 2016. PMID: 27064299
80 results