Denning G - Search Results

1

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction.

Knight KA, Coyle CW, Radford CE, Parker ET, Fedanov A, Shields JM, Szlam F, Purchel A, Chen M, Denning G, Sniecinski RM, Lollar P, Spencer HT, Gaucher EA, Doering CB. Knight KA, et al. Among authors: denning g. Blood Adv. 2021 Sep 14;5(17):3333-3343. doi: 10.1182/bloodadvances.2021004742. Blood Adv. 2021. PMID: 34477814 Free PMC article.

2

Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A.

Dooriss KL, Denning G, Gangadharan B, Javazon EH, McCarty DA, Spencer HT, Doering CB. Dooriss KL, et al. Among authors: denning g. Hum Gene Ther. 2009 May;20(5):465-78. doi: 10.1089/hum.2008.150. Hum Gene Ther. 2009. PMID: 19222367 Free PMC article.

3

Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.

Doering CB, Denning G, Dooriss K, Gangadharan B, Johnston JM, Kerstann KW, McCarty DA, Spencer HT. Doering CB, et al. Among authors: denning g. Mol Ther. 2009 Jul;17(7):1145-54. doi: 10.1038/mt.2009.35. Epub 2009 Mar 3. Mol Ther. 2009. PMID: 19259064 Free PMC article.

4

Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.

Spencer HT, Denning G, Gautney RE, Dropulic B, Roy AJ, Baranyi L, Gangadharan B, Parker ET, Lollar P, Doering CB. Spencer HT, et al. Among authors: denning g. Mol Ther. 2011 Feb;19(2):302-9. doi: 10.1038/mt.2010.239. Epub 2010 Nov 16. Mol Ther. 2011. PMID: 21081907 Free PMC article.

5

Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.

Tran R, Myers DR, Denning G, Shields JE, Lytle AM, Alrowais H, Qiu Y, Sakurai Y, Li WC, Brand O, Le Doux JM, Spencer HT, Doering CB, Lam WA. Tran R, et al. Among authors: denning g. Mol Ther. 2017 Oct 4;25(10):2372-2382. doi: 10.1016/j.ymthe.2017.07.002. Epub 2017 Jul 8. Mol Ther. 2017. PMID: 28780274 Free PMC article.

6

Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A.

Doering CB, Denning G, Shields JE, Fine EJ, Parker ET, Srivastava A, Lollar P, Spencer HT. Doering CB, et al. Among authors: denning g. Hum Gene Ther. 2018 Oct;29(10):1183-1201. doi: 10.1089/hum.2018.137. Hum Gene Ther. 2018. PMID: 30160169 Free PMC article.

7

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr. Smith IW, et al. Among authors: denning g. J Thromb Haemost. 2020 Jan;18(1):57-69. doi: 10.1111/jth.14621. Epub 2019 Sep 8. J Thromb Haemost. 2020. PMID: 31454152 Free PMC article.

8

F5-Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV-short production.

Zimowski KL, Petrillo T, Ho MD, Wechsler J, Shields JE, Denning G, Jhita N, Rivera AA, Escobar MA, Kempton CL, Camire RM, Doering CB. Zimowski KL, et al. Among authors: denning g. J Thromb Haemost. 2021 Jul;19(7):1653-1665. doi: 10.1111/jth.15314. Epub 2021 May 20. J Thromb Haemost. 2021. PMID: 33773040 Free article.

9

Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII.

Russell AL, Prince C, Lundgren TS, Knight KA, Denning G, Alexander JS, Zoine JT, Spencer HT, Chandrakasan S, Doering CB. Russell AL, et al. Among authors: denning g. Mol Ther Methods Clin Dev. 2021 May 5;21:710-727. doi: 10.1016/j.omtm.2021.04.016. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 34141826 Free PMC article.

10

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice.

Lundgren TS, Denning G, Stowell SR, Spencer HT, Doering CB. Lundgren TS, et al. Among authors: denning g. Blood Adv. 2022 Apr 26;6(8):2628-2645. doi: 10.1182/bloodadvances.2021006359. Blood Adv. 2022. PMID: 35286375 Free PMC article.

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