Gaucher EA - Search Results

1

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction.

Knight KA, Coyle CW, Radford CE, Parker ET, Fedanov A, Shields JM, Szlam F, Purchel A, Chen M, Denning G, Sniecinski RM, Lollar P, Spencer HT, Gaucher EA, Doering CB. Knight KA, et al. Among authors: gaucher ea. Blood Adv. 2021 Sep 14;5(17):3333-3343. doi: 10.1182/bloodadvances.2021004742. Blood Adv. 2021. PMID: 34477814 Free PMC article.

2

An experimental phylogeny to benchmark ancestral sequence reconstruction.

Randall RN, Radford CE, Roof KA, Natarajan DK, Gaucher EA. Randall RN, et al. Among authors: gaucher ea. Nat Commun. 2016 Sep 15;7:12847. doi: 10.1038/ncomms12847. Nat Commun. 2016. PMID: 27628687 Free PMC article.

3

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction.

Zakas PM, Brown HC, Knight K, Meeks SL, Spencer HT, Gaucher EA, Doering CB. Zakas PM, et al. Among authors: gaucher ea. Nat Biotechnol. 2017 Jan;35(1):35-37. doi: 10.1038/nbt.3677. Epub 2016 Sep 26. Nat Biotechnol. 2017. PMID: 27669166 Free PMC article.

4

Molecular coevolution of coagulation factor VIII and von Willebrand factor.

Zakas PM, Coyle CW, Brehm A, Bayer M, Solecka-Witulska B, Radford CE, Brown C, Nesbitt K, Dwyer C, Kannicht C, Spencer HT, Gaucher EA, Doering CB, Lillicrap D. Zakas PM, et al. Among authors: gaucher ea. Blood Adv. 2021 Feb 9;5(3):812-822. doi: 10.1182/bloodadvances.2020002971. Blood Adv. 2021. PMID: 33560395 Free PMC article.

5

Ancestral Sequence Reconstruction: From Chemical Paleogenetics to Maximum Likelihood Algorithms and Beyond.

Selberg AGA, Gaucher EA, Liberles DA. Selberg AGA, et al. Among authors: gaucher ea. J Mol Evol. 2021 Apr;89(3):157-164. doi: 10.1007/s00239-021-09993-1. Epub 2021 Jan 24. J Mol Evol. 2021. PMID: 33486547 Free PMC article.

6

Reconstructing evolutionary adaptive paths for protein engineering.

Cole MF, Cox VE, Gratton KL, Gaucher EA. Cole MF, et al. Among authors: gaucher ea. Methods Mol Biol. 2013;978:115-25. doi: 10.1007/978-1-62703-293-3_8. Methods Mol Biol. 2013. PMID: 23423892

7

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Okafor CD, et al. Among authors: gaucher ea. Structure. 2018 Jan 2;26(1):118-129.e3. doi: 10.1016/j.str.2017.11.018. Epub 2017 Dec 21. Structure. 2018. PMID: 29276038 Free PMC article.

8

Phylogenetic Articulation of Uric Acid Evolution in Mammals and How It Informs a Therapeutic Uricase.

Li Z, Hoshino Y, Tran L, Gaucher EA. Li Z, et al. Among authors: gaucher ea. Mol Biol Evol. 2022 Jan 7;39(1):msab312. doi: 10.1093/molbev/msab312. Mol Biol Evol. 2022. PMID: 34718698 Free PMC article.

9

Evolutionary history and metabolic insights of ancient mammalian uricases.

Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Kratzer JT, et al. Among authors: gaucher ea. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3763-8. doi: 10.1073/pnas.1320393111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550457 Free PMC article.

10

Oral Delivery of Nanoparticles Carrying Ancestral Uricase Enzyme Protects against Hyperuricemia in Knockout Mice.

Tran L, Das S, Zhao L, Finn MG, Gaucher EA. Tran L, et al. Among authors: gaucher ea. Biomacromolecules. 2023 May 8;24(5):2003-2008. doi: 10.1021/acs.biomac.2c01388. Epub 2023 Apr 26. Biomacromolecules. 2023. PMID: 37126604 Free PMC article.

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