Spencer HT - Search Results

1

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction.

Knight KA, Coyle CW, Radford CE, Parker ET, Fedanov A, Shields JM, Szlam F, Purchel A, Chen M, Denning G, Sniecinski RM, Lollar P, Spencer HT, Gaucher EA, Doering CB. Knight KA, et al. Among authors: spencer ht. Blood Adv. 2021 Sep 14;5(17):3333-3343. doi: 10.1182/bloodadvances.2021004742. Blood Adv. 2021. PMID: 34477814 Free PMC article.

2

High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells.

Gangadharan B, Parker ET, Ide LM, Spencer HT, Doering CB. Gangadharan B, et al. Among authors: spencer ht. Blood. 2006 May 15;107(10):3859-64. doi: 10.1182/blood-2005-12-4961. Epub 2006 Jan 31. Blood. 2006. PMID: 16449528 Free article.

3

Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity.

Doering CB, Gangadharan B, Dukart HZ, Spencer HT. Doering CB, et al. Among authors: spencer ht. Mol Ther. 2007 Jun;15(6):1093-9. doi: 10.1038/sj.mt.6300146. Epub 2007 Mar 27. Mol Ther. 2007. PMID: 17387335 Free article.

4

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens.

Ide LM, Gangadharan B, Chiang KY, Doering CB, Spencer HT. Ide LM, et al. Among authors: spencer ht. Blood. 2007 Oct 15;110(8):2855-63. doi: 10.1182/blood-2007-04-082602. Epub 2007 Jun 14. Blood. 2007. PMID: 17569821 Free PMC article.

5

Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A.

Dooriss KL, Denning G, Gangadharan B, Javazon EH, McCarty DA, Spencer HT, Doering CB. Dooriss KL, et al. Among authors: spencer ht. Hum Gene Ther. 2009 May;20(5):465-78. doi: 10.1089/hum.2008.150. Hum Gene Ther. 2009. PMID: 19222367 Free PMC article.

6

Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.

Doering CB, Denning G, Dooriss K, Gangadharan B, Johnston JM, Kerstann KW, McCarty DA, Spencer HT. Doering CB, et al. Among authors: spencer ht. Mol Ther. 2009 Jul;17(7):1145-54. doi: 10.1038/mt.2009.35. Epub 2009 Mar 3. Mol Ther. 2009. PMID: 19259064 Free PMC article.

7

Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A.

Ide LM, Iwakoshi NN, Gangadharan B, Jobe S, Moot R, McCarty D, Doering CB, Spencer HT. Ide LM, et al. Among authors: spencer ht. J Gene Med. 2010 Apr;12(4):333-44. doi: 10.1002/jgm.1442. J Gene Med. 2010. PMID: 20209485

8

Advancements in gene transfer-based therapy for hemophilia A.

Doering CB, Spencer HT. Doering CB, et al. Among authors: spencer ht. Expert Rev Hematol. 2009 Dec;2(6):673-683. doi: 10.1586/EHM.09.63. Expert Rev Hematol. 2009. PMID: 20577574 Free PMC article.

9

Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells.

Doering CB, Archer D, Spencer HT. Doering CB, et al. Among authors: spencer ht. Adv Drug Deliv Rev. 2010 Sep 30;62(12):1204-12. doi: 10.1016/j.addr.2010.09.005. Epub 2010 Sep 30. Adv Drug Deliv Rev. 2010. PMID: 20869414 Free PMC article. Review.

10

Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.

Spencer HT, Denning G, Gautney RE, Dropulic B, Roy AJ, Baranyi L, Gangadharan B, Parker ET, Lollar P, Doering CB. Spencer HT, et al. Mol Ther. 2011 Feb;19(2):302-9. doi: 10.1038/mt.2010.239. Epub 2010 Nov 16. Mol Ther. 2011. PMID: 21081907 Free PMC article.

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