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Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level.
Venken K, Hellings N, Thewissen M, Somers V, Hensen K, Rummens JL, Medaer R, Hupperts R, Stinissen P. Venken K, et al. Among authors: hellings n. Immunology. 2008 Jan;123(1):79-89. doi: 10.1111/j.1365-2567.2007.02690.x. Epub 2007 Sep 25. Immunology. 2008. PMID: 17897326 Free PMC article.
Myelin alters the inflammatory phenotype of macrophages by activating PPARs.
Bogie JF, Jorissen W, Mailleux J, Nijland PG, Zelcer N, Vanmierlo T, Van Horssen J, Stinissen P, Hellings N, Hendriks JJ. Bogie JF, et al. Among authors: hellings n. Acta Neuropathol Commun. 2013 Aug 2;1:43. doi: 10.1186/2051-5960-1-43. Acta Neuropathol Commun. 2013. PMID: 24252308 Free PMC article.
Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.
de Bock L, Somers K, Fraussen J, Hendriks JJ, van Horssen J, Rouwette M, Hellings N, Villar LM, Alvarez-Cermeño JC, Espiño M, Hupperts R, Jongen P, Damoiseaux J, Verbeek MM, De Deyn PP, D'hooghe M, Van Wijmeersch B, Stinissen P, Somers V. de Bock L, et al. Among authors: hellings n. J Immunol. 2014 Sep 1;193(5):2147-56. doi: 10.4049/jimmunol.1401166. Epub 2014 Aug 1. J Immunol. 2014. PMID: 25086173 Clinical Trial.
140 results