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A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use.
Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. Myers SJ, et al. Among authors: wilson lj. J Pharmacol Exp Ther. 2021 Oct;379(1):41-52. doi: 10.1124/jpet.120.000370. Epub 2021 Sep 7. J Pharmacol Exp Ther. 2021. PMID: 34493631 Free PMC article.
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, Liotta DC, Traynelis SF, Snyder JP. Tahirovic YA, et al. Among authors: wilson lj. J Med Chem. 2008 Sep 25;51(18):5506-21. doi: 10.1021/jm8002153. J Med Chem. 2008. PMID: 18800760 Free PMC article.
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Mosley CA, Myers SJ, Murray EE, Santangelo R, Tahirovic YA, Kurtkaya N, Mullasseril P, Yuan H, Lyuboslavsky P, Le P, Wilson LJ, Yepes M, Dingledine R, Traynelis SF, Liotta DC. Mosley CA, et al. Among authors: wilson lj. Bioorg Med Chem. 2009 Sep 1;17(17):6463-80. doi: 10.1016/j.bmc.2009.05.085. Epub 2009 Jul 5. Bioorg Med Chem. 2009. PMID: 19648014 Free PMC article.
pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.
Wang H, James ML, Venkatraman TN, Wilson LJ, Lyuboslavsky P, Myers SJ, Lascola CD, Laskowitz DT. Wang H, et al. Among authors: wilson lj. Neurocrit Care. 2014 Feb;20(1):119-31. doi: 10.1007/s12028-013-9944-9. Neurocrit Care. 2014. PMID: 24420693
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.
Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ. Truax VM, et al. Among authors: wilson lj. ACS Med Chem Lett. 2013 Sep 5;4(11):1025-30. doi: 10.1021/ml400183q. eCollection 2013 Nov 14. ACS Med Chem Lett. 2013. PMID: 24936240 Free PMC article.
Discovery of novel N-aryl piperazine CXCR4 antagonists.
Zhao H, Prosser AR, Liotta DC, Wilson LJ. Zhao H, et al. Among authors: wilson lj. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4950-4955. doi: 10.1016/j.bmcl.2015.04.036. Epub 2015 Apr 17. Bioorg Med Chem Lett. 2015. PMID: 25935642 Free PMC article.
243 results