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Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells.
Wimmer S, Deloch L, Hader M, Derer A, Grottker F, Weissmann T, Hecht M, Gostian AO, Fietkau R, Frey B, Gaipl US. Wimmer S, et al. Among authors: grottker f. Int J Mol Sci. 2021 Aug 24;22(17):9114. doi: 10.3390/ijms22179114. Int J Mol Sci. 2021. PMID: 34502022 Free PMC article.
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells.
Grottker F, Gehre S, Reichardt CM, Sengedorj A, Jost T, Rieckmann T, Hecht M, Gostian AO, Frey B, Fietkau R, Gaipl US, Rückert M. Grottker F, et al. Neoplasia. 2023 Nov;45:100944. doi: 10.1016/j.neo.2023.100944. Epub 2023 Oct 17. Neoplasia. 2023. PMID: 37857049 Free PMC article.
Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells.
Gehre S, Meyer F, Sengedorj A, Grottker F, Reichardt CM, Alomo J, Borgmann K, Frey B, Fietkau R, Rückert M, Gaipl US. Gehre S, et al. Among authors: grottker f. Front Oncol. 2023 Apr 20;13:981239. doi: 10.3389/fonc.2023.981239. eCollection 2023. Front Oncol. 2023. PMID: 37152024 Free PMC article.