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Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: leaman dp. iScience. 2021 Aug 17;24(9):102987. doi: 10.1016/j.isci.2021.102987. eCollection 2021 Sep 24. iScience. 2021. PMID: 34505005 Free PMC article.
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T, Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman DD, Burton DR, Zwick MB. Nelson JD, et al. Virology. 2008 Jul 20;377(1):170-83. doi: 10.1016/j.virol.2008.04.005. Epub 2008 May 21. Virology. 2008. PMID: 18499210 Free PMC article.
Dense Array of Spikes on HIV-1 Virion Particles.
Stano A, Leaman DP, Kim AS, Zhang L, Autin L, Ingale J, Gift SK, Truong J, Wyatt RT, Olson AJ, Zwick MB. Stano A, et al. Among authors: leaman dp. J Virol. 2017 Jun 26;91(14):e00415-17. doi: 10.1128/JVI.00415-17. Print 2017 Jul 15. J Virol. 2017. PMID: 28446665 Free PMC article.
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