Liu MM - Search Results

1

Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.

Chen LZ, Zhang XX, Liu MM, Wu J, Ma D, Diao LZ, Li Q, Huang YS, Zhang R, Ruan BF, Liu XH. Chen LZ, et al. Among authors: liu mm, liu xh. J Med Chem. 2021 Sep 23;64(18):13633-13657. doi: 10.1021/acs.jmedchem.1c01007. Epub 2021 Sep 10. J Med Chem. 2021. PMID: 34506712

2

Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.

Shi JB, Chen LZ, Wang BS, Huang X, Jiao MM, Liu MM, Tang WJ, Liu XH. Shi JB, et al. Among authors: liu mm, liu xh. J Med Chem. 2019 Apr 25;62(8):4013-4031. doi: 10.1021/acs.jmedchem.9b00039. Epub 2019 Apr 5. J Med Chem. 2019. PMID: 30925056

3

Design and synthesis of novel pyrazolo[4,3-d]pyrimidines as potential therapeutic agents for acute lung injury.

Wang BS, Huang X, Chen LZ, Liu MM, Shi JB. Wang BS, et al. Among authors: liu mm. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1121-1130. doi: 10.1080/14756366.2019.1618291. J Enzyme Inhib Med Chem. 2019. PMID: 31117832 Free PMC article.

4

Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.

Chen LZ, Shu HY, Wu J, Yu YL, Ma D, Huang X, Liu MM, Liu XH, Shi JB. Chen LZ, et al. Among authors: liu mm, liu xh. Eur J Med Chem. 2021 Mar 5;213:113174. doi: 10.1016/j.ejmech.2021.113174. Epub 2021 Jan 20. Eur J Med Chem. 2021. PMID: 33515864

5

Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy.

Yan YY, Zhang XX, Xiao Y, Shen XB, Jian YJ, Wang YM, She ZH, Liu MM, Liu XH. Yan YY, et al. Among authors: liu mm, liu xh. J Med Chem. 2022 Oct 13;65(19):13216-13239. doi: 10.1021/acs.jmedchem.2c01042. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126227

6

Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor.

Chen X, Yan Y, Zhang Z, Zhang F, Liu M, Du L, Zhang H, Shen X, Zhao D, Shi JB, Liu X. Chen X, et al. J Med Chem. 2021 Aug 26;64(16):11857-11885. doi: 10.1021/acs.jmedchem.1c00104. Epub 2021 Aug 10. J Med Chem. 2021. PMID: 34374541

7

Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents.

Huang X, Wang YS, Ma D, Wang YY, Bian SD, Zhang B, Qiao Y, He ZR, Lv M, Cai GL, Wang ZX, Liu XS, Shi JB, Liu MM. Huang X, et al. Among authors: liu mm, liu xs. Eur J Med Chem. 2022 Feb 15;230:114112. doi: 10.1016/j.ejmech.2022.114112. Epub 2022 Jan 11. Eur J Med Chem. 2022. PMID: 35065411

8

Discovery and SARs of 5-Chloro-N⁴-phenyl-N²-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors with Potent Antitumor Activity.

Wang Y, Chen X, Yan Y, Zhu X, Liu M, Liu X. Wang Y, et al. J Med Chem. 2020 Mar 26;63(6):3327-3347. doi: 10.1021/acs.jmedchem.9b02121. Epub 2020 Mar 12. J Med Chem. 2020. PMID: 32129996

9

Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo.

Yan Y, Xing C, Xiao Y, Shen X, Zhang Z, He C, Shi JB, Liu M, Liu X. Yan Y, et al. J Med Chem. 2022 May 26;65(10):7334-7362. doi: 10.1021/acs.jmedchem.2c00356. Epub 2022 May 10. J Med Chem. 2022. PMID: 35536548

10

Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis.

Liu M, Liang Y, Zhu Z, Wang J, Cheng X, Cheng J, Xu B, Li R, Liu X, Wang Y. Liu M, et al. J Med Chem. 2019 Oct 24;62(20):9299-9314. doi: 10.1021/acs.jmedchem.9b01313. Epub 2019 Oct 4. J Med Chem. 2019. PMID: 31556611

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