Zhang R - Search Results

1

Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.

Chen LZ, Zhang XX, Liu MM, Wu J, Ma D, Diao LZ, Li Q, Huang YS, Zhang R, Ruan BF, Liu XH. Chen LZ, et al. Among authors: zhang r, zhang xx. J Med Chem. 2021 Sep 23;64(18):13633-13657. doi: 10.1021/acs.jmedchem.1c01007. Epub 2021 Sep 10. J Med Chem. 2021. PMID: 34506712

2

Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.

Wang X, Feng YL, Zhao XY, An R, Cao C, Guo MB, Zhang R, Wang YX, Hou Z, Guo C. Wang X, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2021 Dec 1;53:128420. doi: 10.1016/j.bmcl.2021.128420. Epub 2021 Oct 30. Bioorg Med Chem Lett. 2021. PMID: 34728369

3

Multifunctional silicon calcium phosphate composite scaffolds promote stem cell recruitment and bone regeneration.

Zhang R, He Y, Tao B, Wu J, Hu X, Li X, Xia Z, Cai K. Zhang R, et al. J Mater Chem B. 2022 Jul 13;10(27):5218-5230. doi: 10.1039/d2tb00687a. J Mater Chem B. 2022. PMID: 35737023

4

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Zhang R, Li H, Zhang X, Li J, Su H, Lu Q, Dong G, Dou H, Fan C, Gu Z, Mu Q, Tang W, Xu Y, Liu H. Zhang R, et al. Among authors: zhang x. Eur J Med Chem. 2021 Feb 5;211:113004. doi: 10.1016/j.ejmech.2020.113004. Epub 2020 Nov 7. Eur J Med Chem. 2021. PMID: 33218684

5

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Zhang X, Dong G, Li H, Chen W, Li J, Feng C, Gu Z, Zhu F, Zhang R, Li M, Tang W, Liu H, Xu Y. Zhang X, et al. Among authors: zhang r. J Med Chem. 2019 Jun 13;62(11):5579-5593. doi: 10.1021/acs.jmedchem.9b00518. Epub 2019 May 31. J Med Chem. 2019. PMID: 31099559

6

Design and synthesis of novel 2-arylbenzimidazoles as selective mutant isocitrate dehydrogenase 2 R140Q inhibitors.

Li Z, Wu X, Jia L, Li J, Zhang R, Tang H, Li Z, Bu H, Shen C. Li Z, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2020 May 1;30(9):127070. doi: 10.1016/j.bmcl.2020.127070. Epub 2020 Feb 28. Bioorg Med Chem Lett. 2020. PMID: 32143887

7

N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations.

Cheng H, Yang L, Liu HF, Zhang R, Chen C, Wu Y, Jiang W. Cheng H, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127302. doi: 10.1016/j.bmcl.2020.127302. Epub 2020 Jun 3. Bioorg Med Chem Lett. 2020. PMID: 32631522

8

Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.

Yang Y, Yu D, Zhu X, Du G, Wang W, Zou F, Wang H, Zhang R, Ye L, Tian J. Yang Y, et al. Among authors: zhang r. Eur J Med Chem. 2021 Nov 15;224:113718. doi: 10.1016/j.ejmech.2021.113718. Epub 2021 Jul 24. Eur J Med Chem. 2021. PMID: 34329999

9

Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents.

Li B, Wang K, Zhang R, Li B, Shen Y, Ji Q. Li B, et al. Among authors: zhang r. Eur J Med Chem. 2019 Nov 15;182:111669. doi: 10.1016/j.ejmech.2019.111669. Epub 2019 Aug 31. Eur J Med Chem. 2019. PMID: 31494473

10

Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51.

Xu H, Mou YH, Guo MB, Zhang R, Yan ZZ, An R, Wang X, Su X, Hou Z, Guo C. Xu H, et al. Among authors: zhang r. Eur J Med Chem. 2022 Dec 5;243:114707. doi: 10.1016/j.ejmech.2022.114707. Epub 2022 Aug 28. Eur J Med Chem. 2022. PMID: 36057236

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