Zhang XX - Search Results

1

Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.

Chen LZ, Zhang XX, Liu MM, Wu J, Ma D, Diao LZ, Li Q, Huang YS, Zhang R, Ruan BF, Liu XH. Chen LZ, et al. Among authors: zhang r, zhang xx. J Med Chem. 2021 Sep 23;64(18):13633-13657. doi: 10.1021/acs.jmedchem.1c01007. Epub 2021 Sep 10. J Med Chem. 2021. PMID: 34506712

2

Metalloprotein Inhibitors for the Treatment of Human Diseases.

Yang Y, Hu XQ, Li QS, Zhang XX, Ruan BF, Xu J, Liao C. Yang Y, et al. Among authors: zhang xx. Curr Top Med Chem. 2016;16(4):384-96. doi: 10.2174/1568026615666150813145218. Curr Top Med Chem. 2016. PMID: 26268345 Review.

3

Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.

Ruan BF, Cheng HJ, Ren J, Li HL, Guo LL, Zhang XX, Liao C. Ruan BF, et al. Among authors: zhang xx. Eur J Med Chem. 2015 Oct 20;103:185-90. doi: 10.1016/j.ejmech.2015.08.055. Epub 2015 Sep 1. Eur J Med Chem. 2015. PMID: 26352677

4

Perspectives in Medicinal Chemistry: Metalloprotein Inhibitors: What Have We Made and What is the Next Step?

Zhang XX, Liao C. Zhang XX, et al. Curr Top Med Chem. 2016;16(5):467-9. doi: 10.2174/156802661605151022150043. Curr Top Med Chem. 2016. PMID: 26510684 No abstract available.

5

Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold.

Zhan MM, Yang Y, Luo J, Zhang XX, Xiao X, Li S, Cheng K, Xie Z, Tu Z, Liao C. Zhan MM, et al. Among authors: zhang xx. Eur J Med Chem. 2018 Jan 1;143:724-731. doi: 10.1016/j.ejmech.2017.11.058. Epub 2017 Nov 23. Eur J Med Chem. 2018. PMID: 29220793

6

Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.

Xiao X, Zhang XX, Zhan MM, Cheng K, Li S, Xie Z, Liao C. Xiao X, et al. Among authors: zhang xx. Eur J Med Chem. 2018 Feb 10;145:588-593. doi: 10.1016/j.ejmech.2018.01.029. Epub 2018 Jan 10. Eur J Med Chem. 2018. PMID: 29339253

7

Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis.

Zhang XX, Diao LZ, Chen LZ, Ma D, Wang YM, Jiang H, Ruan BF, Liu XH. Zhang XX, et al. Eur J Med Chem. 2022 Jun 5;236:114357. doi: 10.1016/j.ejmech.2022.114357. Epub 2022 Apr 7. Eur J Med Chem. 2022. PMID: 35428012

8

Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer.

Zhang XX, Xiao Y, Yan YY, Wang YM, Jiang H, Wu L, Shi JB, Liu XH. Zhang XX, et al. J Med Chem. 2022 Sep 22;65(18):12095-12123. doi: 10.1021/acs.jmedchem.2c00820. Epub 2022 Sep 6. J Med Chem. 2022. PMID: 36068975

9

Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy.

Yan YY, Zhang XX, Xiao Y, Shen XB, Jian YJ, Wang YM, She ZH, Liu MM, Liu XH. Yan YY, et al. Among authors: zhang xx. J Med Chem. 2022 Oct 13;65(19):13216-13239. doi: 10.1021/acs.jmedchem.2c01042. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126227

10

Discovery of pterostilbene analogs as novel NLRP3 inflammasome inhibitors for potential treatment of DSS-induced colitis in mice.

Ruan B, Rong M, Ming Z, Wang K, Liu X, Deng L, Zhang X, Xu K, Shi C, Gao T, Liu X, Chen L. Ruan B, et al. Bioorg Chem. 2023 Apr;133:106429. doi: 10.1016/j.bioorg.2023.106429. Epub 2023 Feb 18. Bioorg Chem. 2023. PMID: 36841048

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