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Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models.
Schneider MA, Heeb L, Beffinger MM, Pantelyushin S, Linecker M, Roth L, Lehmann K, Ungethüm U, Kobold S, Graf R, van den Broek M, Vom Berg J, Gupta A, Clavien PA. Schneider MA, et al. Among authors: kobold s. Sci Transl Med. 2021 Sep 15;13(611):eabc8188. doi: 10.1126/scitranslmed.abc8188. Epub 2021 Sep 15. Sci Transl Med. 2021. PMID: 34524861
Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy.
Karches CH, Benmebarek MR, Schmidbauer ML, Kurzay M, Klaus R, Geiger M, Rataj F, Cadilha BL, Lesch S, Heise C, Murr R, Vom Berg J, Jastroch M, Lamp D, Ding J, Duewell P, Niederfellner G, Sustmann C, Endres S, Klein C, Kobold S. Karches CH, et al. Among authors: kobold s. Clin Cancer Res. 2019 Oct 1;25(19):5890-5900. doi: 10.1158/1078-0432.CCR-18-3927. Epub 2019 Jul 8. Clin Cancer Res. 2019. PMID: 31285373 Free PMC article.
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
Ruzicka M, Koenig LM, Formisano S, Boehmer DFR, Vick B, Heuer EM, Meinl H, Kocheise L, Zeitlhöfler M, Ahlfeld J, Kobold S, Endres S, Subklewe M, Duewell P, Schnurr M, Jeremias I, Lichtenegger FS, Rothenfusser S. Ruzicka M, et al. Among authors: kobold s. Leukemia. 2020 Apr;34(4):1017-1026. doi: 10.1038/s41375-019-0639-x. Epub 2019 Nov 18. Leukemia. 2020. PMID: 31740809 Free PMC article.
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Prokopi A, Tripp CH, Tummers B, Hornsteiner F, Spoeck S, Crawford JC, Clements DR, Efremova M, Hutter K, Bellmann L, Cappellano G, Cadilha BL, Kobold S, Boon L, Ortner D, Trajanoski Z, Chen S, de Gruijl TD, Idoyaga J, Green DR, Stoitzner P. Prokopi A, et al. Among authors: kobold s. J Immunother Cancer. 2021 Jan;9(1):e000832. doi: 10.1136/jitc-2020-000832. J Immunother Cancer. 2021. PMID: 33408092 Free PMC article.
Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel.
Sams L, Kruger S, Heinemann V, Bararia D, Haebe S, Alig S, Haas M, Zhang D, Westphalen CB, Ormanns S, Metzger P, Werner J, Weigert O, von Bergwelt-Baildon M, Rataj F, Kobold S, Boeck S. Sams L, et al. Among authors: kobold s. Clin Transl Oncol. 2021 Nov;23(11):2394-2401. doi: 10.1007/s12094-021-02620-x. Epub 2021 Apr 19. Clin Transl Oncol. 2021. PMID: 33876417 Free PMC article.
Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity.
Fernandez-Rodriguez L, Cianciaruso C, Bill R, Trefny MP, Klar R, Kirchhammer N, Buchi M, Festag J, Michel S, Kohler RH, Jones E, Maaske A, Vom Berg J, Kobold S, Kashyap AS, Jaschinski F, Dixon KO, Pittet MJ, Zippelius A. Fernandez-Rodriguez L, et al. Among authors: kobold s. J Immunother Cancer. 2023 May;11(5):e006714. doi: 10.1136/jitc-2023-006714. J Immunother Cancer. 2023. PMID: 37208130 Free PMC article.
HDR-based CRISPR/Cas9-mediated Knockout of PD-L1 in C57BL/6 Mice.
Heeb LV, Taskoparan B, Katsoulas A, Beffinger M, Clavien PA, Kobold S, Gupta A, Berg JV. Heeb LV, et al. Among authors: kobold s. Bio Protoc. 2023 Jul 20;13(14):e4724. doi: 10.21769/BioProtoc.4724. eCollection 2023 Jul 20. Bio Protoc. 2023. PMID: 37497456 Free PMC article.
PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis.
Blobner J, Dengler L, Eberle C, Herold JJ, Xu T, Beck A, Mühlbauer A, Müller KJ, Teske N, Karschnia P, van den Heuvel D, Schallerer F, Ishikawa-Ankerhold H, Thon N, Tonn JC, Subklewe M, Kobold S, Harter PN, Buchholz VR, von Baumgarten L. Blobner J, et al. Among authors: kobold s. Cancer Immunol Immunother. 2024 Oct 3;73(12):255. doi: 10.1007/s00262-024-03837-9. Cancer Immunol Immunother. 2024. PMID: 39358663 Free PMC article.
155 results