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Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.
Popadynec M, Baradaran-Heravi A, Alford B, Cameron SA, Clinch K, Mason JM, Rendle PM, Zubkova OV, Gan Z, Liu H, Rebollo O, Whitfield DM, Yan F, Roberge M, Powell DA. Popadynec M, et al. Among authors: clinch k. ACS Med Chem Lett. 2021 Aug 9;12(9):1486-1492. doi: 10.1021/acsmedchemlett.1c00349. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34531957 Free PMC article.
Immucillins in custom catalytic-site cavities.
Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL. Murkin AS, et al. Among authors: clinch k. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. doi: 10.1016/j.bmcl.2008.08.047. Epub 2008 Aug 19. Bioorg Med Chem Lett. 2008. PMID: 18778937 Free PMC article.
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.
Clinch K, Evans GB, Fröhlich RF, Gulab SA, Gutierrez JA, Mason JM, Schramm VL, Tyler PC, Woolhouse AD. Clinch K, et al. Bioorg Med Chem. 2012 Sep 1;20(17):5181-7. doi: 10.1016/j.bmc.2012.07.006. Epub 2012 Jul 14. Bioorg Med Chem. 2012. PMID: 22854195 Free PMC article.
New Antibiotic Candidates against Helicobacter pylori.
Wang S, Cameron SA, Clinch K, Evans GB, Wu Z, Schramm VL, Tyler PC. Wang S, et al. Among authors: clinch k. J Am Chem Soc. 2015 Nov 18;137(45):14275-80. doi: 10.1021/jacs.5b06110. Epub 2015 Nov 9. J Am Chem Soc. 2015. PMID: 26494017 Free PMC article.
Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability.
Mutreja I, Warring SL, Lim KS, Swadi T, Clinch K, Mason JM, Sheen CR, Thompson DR, Ducati RG, Chambers ST, Evans GB, Gerth ML, Miller AG, Woodfield TBF. Mutreja I, et al. Among authors: clinch k. ACS Biomater Sci Eng. 2019 Feb 11;5(2):748-758. doi: 10.1021/acsbiomaterials.8b01141. Epub 2019 Jan 10. ACS Biomater Sci Eng. 2019. PMID: 33405836
37 results