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IP3R-driven increases in mitochondrial Ca2+ promote neuronal death in NPC disease.
Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2110629118. doi: 10.1073/pnas.2110629118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34580197
Free PMC article.
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability.
Vivas O, Tiscione SA, Dixon RE, Ory DS, Dickson EJ.
Vivas O, et al. Among authors: tiscione sa.
Cell Rep. 2019 May 28;27(9):2636-2648.e4. doi: 10.1016/j.celrep.2019.04.099.
Cell Rep. 2019.
PMID: 31141688
Free PMC article.
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Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.
Tiscione SA, Vivas O, Ginsburg KS, Bers DM, Ory DS, Santana LF, Dixon RE, Dickson EJ.
Tiscione SA, et al.
J Cell Biol. 2019 Dec 2;218(12):4141-4156. doi: 10.1083/jcb.201903018. Epub 2019 Oct 10.
J Cell Biol. 2019.
PMID: 31601621
Free PMC article.
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NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes.
Kutchukian C, Vivas O, Casas M, Jones JG, Tiscione SA, Simó S, Ory DS, Dixon RE, Dickson EJ.
Kutchukian C, et al. Among authors: tiscione sa.
EMBO J. 2021 Jul 1;40(13):e105990. doi: 10.15252/embj.2020105990. Epub 2021 May 21.
EMBO J. 2021.
PMID: 34019311
Free PMC article.
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