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452 results

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A prenylated dsRNA sensor protects against severe COVID-19.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G; ISARIC4C Investigators; Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. Wickenhagen A, et al. Among authors: castello a. Science. 2021 Oct 29;374(6567):eabj3624. doi: 10.1126/science.abj3624. Epub 2021 Oct 29. Science. 2021. PMID: 34581622 Free PMC article.
The new (dis)order in RNA regulation.
Järvelin AI, Noerenberg M, Davis I, Castello A. Järvelin AI, et al. Among authors: castello a. Cell Commun Signal. 2016 Apr 6;14:9. doi: 10.1186/s12964-016-0132-3. Cell Commun Signal. 2016. PMID: 27048167 Free PMC article. Review.
HIV Rev-isited.
Truman CT, Järvelin A, Davis I, Castello A. Truman CT, et al. Among authors: castello a. Open Biol. 2020 Dec;10(12):200320. doi: 10.1098/rsob.200320. Epub 2020 Dec 23. Open Biol. 2020. PMID: 33352061 Free PMC article. Review.
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Wing PAC, Keeley TP, Zhuang X, Lee JY, Prange-Barczynska M, Tsukuda S, Morgan SB, Harding AC, Argles ILA, Kurlekar S, Noerenberg M, Thompson CP, Huang KA, Balfe P, Watashi K, Castello A, Hinks TSC, James W, Ratcliffe PJ, Davis I, Hodson EJ, Bishop T, McKeating JA. Wing PAC, et al. Among authors: castello a. Cell Rep. 2021 Apr 20;35(3):109020. doi: 10.1016/j.celrep.2021.109020. Epub 2021 Apr 5. Cell Rep. 2021. PMID: 33852916 Free PMC article.
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.
Kamel W, Noerenberg M, Cerikan B, Chen H, Järvelin AI, Kammoun M, Lee JY, Shuai N, Garcia-Moreno M, Andrejeva A, Deery MJ, Johnson N, Neufeldt CJ, Cortese M, Knight ML, Lilley KS, Martinez J, Davis I, Bartenschlager R, Mohammed S, Castello A. Kamel W, et al. Among authors: castello a. Mol Cell. 2021 Jul 1;81(13):2851-2867.e7. doi: 10.1016/j.molcel.2021.05.023. Epub 2021 May 24. Mol Cell. 2021. PMID: 34118193 Free PMC article.
The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.
Shaw AE, Rihn SJ, Mollentze N, Wickenhagen A, Stewart DG, Orton RJ, Kuchi S, Bakshi S, Collados MR, Turnbull ML, Busby J, Gu Q, Smollett K, Bamford CGG, Sugrue E, Johnson PCD, Da Silva AF, Castello A, Streicker DG, Robertson DL, Palmarini M, Wilson SJ. Shaw AE, et al. Among authors: castello a. PLoS Biol. 2021 Sep 7;19(9):e3001352. doi: 10.1371/journal.pbio.3001352. eCollection 2021 Sep. PLoS Biol. 2021. PMID: 34491982 Free PMC article.
Uncovering viral RNA-host cell interactions on a proteome-wide scale.
Iselin L, Palmalux N, Kamel W, Simmonds P, Mohammed S, Castello A. Iselin L, et al. Among authors: castello a. Trends Biochem Sci. 2022 Jan;47(1):23-38. doi: 10.1016/j.tibs.2021.08.002. Epub 2021 Sep 9. Trends Biochem Sci. 2022. PMID: 34509361 Free PMC article. Review.
Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.
Lee JY, Wing PAC, Gala DS, Noerenberg M, Järvelin AI, Titlow J, Zhuang X, Palmalux N, Iselin L, Thompson MK, Parton RM, Prange-Barczynska M, Wainman A, Salguero FJ, Bishop T, Agranoff D, James W, Castello A, McKeating JA, Davis I. Lee JY, et al. Among authors: castello a. Elife. 2022 Jan 20;11:e74153. doi: 10.7554/eLife.74153. Elife. 2022. PMID: 35049501 Free PMC article.
452 results