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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T. Kubota N, et al. Among authors: terauchi y. Diabetes. 2000 Nov;49(11):1880-9. doi: 10.2337/diabetes.49.11.1880. Diabetes. 2000. PMID: 11078455
Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.
Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T. Matsui J, et al. Among authors: terauchi y. Diabetes. 2004 Nov;53(11):2844-54. doi: 10.2337/diabetes.53.11.2844. Diabetes. 2004. PMID: 15504964
Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabetes.
Iwasaki T, Togashi Y, Ohshige K, Yoneda M, Fujita K, Nakajima A, Terauchi Y. Iwasaki T, et al. Among authors: terauchi y. Diabetes Res Clin Pract. 2008 Mar;79(3):427-32. doi: 10.1016/j.diabres.2007.10.035. Epub 2008 Jan 22. Diabetes Res Clin Pract. 2008. PMID: 18207278
507 results