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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. Gyimesi M, et al. Among authors: malnasi csizmadia a. Cell. 2020 Oct 15;183(2):335-346.e13. doi: 10.1016/j.cell.2020.08.050. Epub 2020 Oct 8. Cell. 2020. PMID: 33035452 Free PMC article.
Azidoblebbistatin, a photoreactive myosin inhibitor.
Képiró M, Várkuti BH, Bodor A, Hegyi G, Drahos L, Kovács M, Málnási-Csizmadia A. Képiró M, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9402-7. doi: 10.1073/pnas.1202786109. Epub 2012 May 30. Proc Natl Acad Sci U S A. 2012. PMID: 22647605 Free PMC article.
Molecular tattoo: subcellular confinement of drug effects.
Képiró M, Várkuti BH, Rauscher AA, Kellermayer MSZ, Varga M, Málnási-Csizmadia A. Képiró M, et al. Chem Biol. 2015 Apr 23;22(4):548-558. doi: 10.1016/j.chembiol.2015.03.013. Epub 2015 Apr 16. Chem Biol. 2015. PMID: 25892202
Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2.
Gyimesi M, Rauscher AÁ, Suthar SK, Hamow KÁ, Oravecz K, Lőrincz I, Borhegyi Z, Déri MT, Kiss ÁF, Monostory K, Szabó PT, Nag S, Tomasic I, Krans J, Tierney PJ, Kovács M, Kornya L, Málnási-Csizmadia A. Gyimesi M, et al. Among authors: malnasi csizmadia a. J Pharmacol Exp Ther. 2021 Mar;376(3):358-373. doi: 10.1124/jpet.120.000167. Epub 2021 Jan 19. J Pharmacol Exp Ther. 2021. PMID: 33468641
67 results