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Expanding Bromodomain Targeting into Neglected Parasitic Diseases.
Tallant C, Bamborough P, Chung CW, Gamo FJ, Kirkpatrick R, Larminie C, Martín J, Prinjha R, Rioja I, Simola DF, Gabarró R, Calderón F. Tallant C, et al. Among authors: martin j. ACS Infect Dis. 2021 Nov 12;7(11):2953-2958. doi: 10.1021/acsinfecdis.1c00387. Epub 2021 Oct 6. ACS Infect Dis. 2021. PMID: 34612618
Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine.
Armitage EG, Alqaisi AQI, Godzien J, Peña I, Mbekeani AJ, Alonso-Herranz V, López-Gonzálvez Á, Martín J, Gabarro R, Denny PW, Barrett MP, Barbas C. Armitage EG, et al. Among authors: martin j. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02095-17. doi: 10.1128/AAC.02095-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463533 Free PMC article.
Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis.
Armitage EG, Godzien J, Peña I, López-Gonzálvez Á, Angulo S, Gradillas A, Alonso-Herranz V, Martín J, Fiandor JM, Barrett MP, Gabarro R, Barbas C. Armitage EG, et al. Among authors: martin j. ACS Chem Biol. 2018 May 18;13(5):1361-1369. doi: 10.1021/acschembio.8b00204. Epub 2018 Apr 24. ACS Chem Biol. 2018. PMID: 29671577 Free article.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nühs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG. Wyllie S, et al. Among authors: martin j. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9318-9323. doi: 10.1073/pnas.1820175116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962368 Free PMC article.
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani.
Wall RJ, Carvalho S, Milne R, Bueren-Calabuig JA, Moniz S, Cantizani-Perez J, MacLean L, Kessler A, Cotillo I, Sastry L, Manthri S, Patterson S, Zuccotto F, Thompson S, Martin J, Marco M, Miles TJ, De Rycker M, Thomas MG, Fairlamb AH, Gilbert IH, Wyllie S. Wall RJ, et al. Among authors: martin j. ACS Infect Dis. 2020 Mar 13;6(3):515-528. doi: 10.1021/acsinfecdis.9b00426. Epub 2020 Jan 30. ACS Infect Dis. 2020. PMID: 31967783 Free PMC article.
Essential Bromodomain TcBDF2 as a Drug Target against Chagas Disease.
Pezza A, Tavernelli LE, Alonso VL, Perdomo V, Gabarro R, Prinjha R, Rodríguez Araya E, Rioja I, Docampo R, Calderón F, Martin J, Serra E. Pezza A, et al. Among authors: martin j. ACS Infect Dis. 2022 May 13;8(5):1062-1074. doi: 10.1021/acsinfecdis.2c00057. Epub 2022 Apr 28. ACS Infect Dis. 2022. PMID: 35482332
Bromodomain factor 5 is an essential regulator of transcription in Leishmania.
Jones NG, Geoghegan V, Moore G, Carnielli JBT, Newling K, Calderón F, Gabarró R, Martín J, Prinjha RK, Rioja I, Wilkinson AJ, Mottram JC. Jones NG, et al. Among authors: martin j. Nat Commun. 2022 Jul 13;13(1):4071. doi: 10.1038/s41467-022-31742-1. Nat Commun. 2022. PMID: 35831302 Free PMC article.
Identification of novel bromodomain inhibitors of Trypanosoma cruzi bromodomain factor 2 (TcBDF2) using a fluorescence polarization-based high-throughput assay.
Tavernelli LE, Alonso VL, Peña I, Rodríguez Araya E, Manarin R, Cantizani J, Martin J, Salamanca J, Bamborough P, Calderón F, Gabarro R, Serra E. Tavernelli LE, et al. Among authors: martin j. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0024324. doi: 10.1128/aac.00243-24. Epub 2024 Jul 19. Antimicrob Agents Chemother. 2024. PMID: 39028190 Free PMC article.
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