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Pharmacological tools to target NKCC1 in brain disorders.
Savardi A, Borgogno M, De Vivo M, Cancedda L. Savardi A, et al. Among authors: cancedda l. Trends Pharmacol Sci. 2021 Dec;42(12):1009-1034. doi: 10.1016/j.tips.2021.09.005. Epub 2021 Oct 4. Trends Pharmacol Sci. 2021. PMID: 34620512 Free article. Review.
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.
Parrini M, Naskar S, Alberti M, Colombi I, Morelli G, Rocchi A, Nanni M, Piccardi F, Charles S, Ronzitti G, Mingozzi F, Contestabile A, Cancedda L. Parrini M, et al. Among authors: cancedda l. Mol Ther. 2021 Oct 6;29(10):3072-3092. doi: 10.1016/j.ymthe.2021.05.023. Epub 2021 May 29. Mol Ther. 2021. PMID: 34058387 Free PMC article.
Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome.
Borgogno M, Savardi A, Manigrasso J, Turci A, Portioli C, Ottonello G, Bertozzi SM, Armirotti A, Contestabile A, Cancedda L, De Vivo M. Borgogno M, et al. Among authors: cancedda l. J Med Chem. 2021 Jul 22;64(14):10203-10229. doi: 10.1021/acs.jmedchem.1c00603. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34137257 Free PMC article.
67 results