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T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF. Marchelletta RR, et al. Among authors: canale v. J Clin Invest. 2021 Sep 1;131(17):e138230. doi: 10.1172/JCI138230. J Clin Invest. 2021. PMID: 34623320 Free PMC article.
The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli.
Shawki A, Ramirez R, Spalinger MR, Ruegger PM, Sayoc-Becerra A, Santos AN, Chatterjee P, Canale V, Mitchell JD, Macbeth JC, Gries CM, Tremblay ML, Hsiao A, Borneman J, McCole DF. Shawki A, et al. Among authors: canale v. Gut Microbes. 2020 Nov 1;11(6):1547-1566. doi: 10.1080/19490976.2020.1775538. Epub 2020 Jun 26. Gut Microbes. 2020. PMID: 32586195 Free PMC article.
PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
Spalinger MR, Sayoc-Becerra A, Santos AN, Shawki A, Canale V, Krishnan M, Niechcial A, Obialo N, Scharl M, Li J, Nair MG, McCole DF. Spalinger MR, et al. Among authors: canale v. Gastroenterology. 2020 Nov;159(5):1763-1777.e14. doi: 10.1053/j.gastro.2020.07.004. Epub 2020 Jul 9. Gastroenterology. 2020. PMID: 32652144 Free PMC article.
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.
Canale V, Spalinger MR, Alvarez R, Sayoc-Becerra A, Sanati G, Manz S, Chatterjee P, Santos AN, Lei H, Jahng S, Chu T, Shawki A, Hanson E, Eckmann L, Ouellette AJ, McCole DF. Canale V, et al. Cell Mol Gastroenterol Hepatol. 2023;16(1):39-62. doi: 10.1016/j.jcmgh.2023.03.009. Epub 2023 Apr 7. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37030630 Free PMC article.
Respiratory exposure to agricultural dust extract promotes increased intestinal Tnfα expression, gut barrier dysfunction, and endotoxemia in mice.
Crawford MS, Ulu A, Ramirez BM, Santos AN, Chatterjee P, Canale V, Manz S, Lei H, Nordgren TM, McCole DF. Crawford MS, et al. Among authors: canale v. Am J Physiol Gastrointest Liver Physiol. 2024 Jan 1;326(1):G3-G15. doi: 10.1152/ajpgi.00297.2022. Epub 2023 Oct 24. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 37874654 Free PMC article.
The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene, PTPN2.
Chatterjee P, Canale V, King SJ, Shawki A, Lei H, Haddad M, Gries CM, McGovern DPB, Borneman J, McCole DF. Chatterjee P, et al. Among authors: canale v. medRxiv [Preprint]. 2024 Sep 28:2024.09.26.24314341. doi: 10.1101/2024.09.26.24314341. medRxiv. 2024. PMID: 39399045 Free PMC article. Preprint.
383 results