Inoue A - Search Results

1

A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor.

Inoue A, Janke LJ, Gudenas BL, Jin H, Fan Y, Paré J, Clay MR, Northcott PA, Hirbe AC, Cao X. Inoue A, et al. Neurooncol Adv. 2021 Sep 10;3(1):vdab129. doi: 10.1093/noajnl/vdab129. eCollection 2021 Jan-Dec. Neurooncol Adv. 2021. PMID: 34647023 Free PMC article.

2

Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.

Inoue A, Li T, Roby SK, Valentine MB, Inoue M, Boyd K, Kidd VJ, Lahti JM. Inoue A, et al. Among authors: inoue m. Cell Cycle. 2007 Jul 1;6(13):1646-54. doi: 10.4161/cc.6.13.4411. Epub 2007 May 8. Cell Cycle. 2007. PMID: 17611414

3

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.

Moritake H, Obara M, Saito Y, Kashimada A, Takagi M, Funakoshi-Tago M, Fukuyama T, Yoshioka M, Inoue A, Komatsu H, Nishitoh H, Kataoka H, Nunoi H. Moritake H, et al. Among authors: inoue a. Hum Cell. 2017 Apr;30(2):88-97. doi: 10.1007/s13577-016-0153-7. Epub 2016 Nov 24. Hum Cell. 2017. PMID: 27885588

4

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.

Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N. Punchihewa C, et al. Among authors: inoue a. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1. J Biol Chem. 2012. PMID: 22383522 Free PMC article.

5

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.

Actis M, Inoue A, Evison B, Perry S, Punchihewa C, Fujii N. Actis M, et al. Among authors: inoue a. Bioorg Med Chem. 2013 Apr 1;21(7):1972-7. doi: 10.1016/j.bmc.2013.01.022. Epub 2013 Jan 22. Bioorg Med Chem. 2013. PMID: 23395113

6

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance.

Vanarotti M, Evison BJ, Actis ML, Inoue A, McDonald ET, Shao Y, Heath RJ, Fujii N. Vanarotti M, et al. Among authors: inoue a. Bioorg Med Chem. 2018 May 15;26(9):2345-2353. doi: 10.1016/j.bmc.2018.03.028. Epub 2018 Mar 19. Bioorg Med Chem. 2018. PMID: 29598900 Free PMC article.

7

A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. Inoue A, et al. J Biol Chem. 2014 Mar 7;289(10):7109-7120. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28. J Biol Chem. 2014. PMID: 24474685 Free PMC article.

8

Mammalian ChlR1 has a role in heterochromatin organization.

Inoue A, Hyle J, Lechner MS, Lahti JM. Inoue A, et al. Exp Cell Res. 2011 Oct 15;317(17):2522-35. doi: 10.1016/j.yexcr.2011.08.006. Epub 2011 Aug 11. Exp Cell Res. 2011. PMID: 21854770 Free PMC article.

9

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.

Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT. Inukai T, et al. Among authors: inoue a. Mol Cell. 1999 Sep;4(3):343-52. doi: 10.1016/s1097-2765(00)80336-6. Mol Cell. 1999. PMID: 10518215 Free article.

10

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.

Fujii N, Evison BJ, Actis ML, Inoue A. Fujii N, et al. Among authors: inoue a. Bioorg Med Chem. 2015 Nov 1;23(21):6912-21. doi: 10.1016/j.bmc.2015.09.045. Epub 2015 Sep 30. Bioorg Med Chem. 2015. PMID: 26462050 Free PMC article.

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