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Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.
Lipskaia L, Maisonnasse P, Fouillade C, Sencio V, Pascal Q, Flaman JM, Born E, Londono-Vallejo A, Le Grand R, Bernard D, Trottein F, Adnot S. Lipskaia L, et al. Among authors: flaman jm. Am J Respir Cell Mol Biol. 2022 Jan;66(1):107-111. doi: 10.1165/rcmb.2021-0205LE. Am J Respir Cell Mol Biol. 2022. PMID: 34648725 Free PMC article. No abstract available.
The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice.
Breau M, Houssaini A, Lipskaia L, Abid S, Born E, Marcos E, Czibik G, Attwe A, Beaulieu D, Palazzo A, Flaman JM, Bourachot B, Collin G, Tran Van Nhieu J, Bernard D, Mechta-Grigoriou F, Adnot S. Breau M, et al. Among authors: flaman jm. JCI Insight. 2019 Oct 3;4(19):e127647. doi: 10.1172/jci.insight.127647. JCI Insight. 2019. PMID: 31578304 Free PMC article.
Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A.
Zhao Y, Wu Z, Chanal M, Guillaumond F, Goehrig D, Bachy S, Principe M, Ziverec A, Flaman JM, Collin G, Tomasini R, Pasternack A, Ritvos O, Vasseur S, Bernard D, Hennino A, Bertolino P. Zhao Y, et al. Among authors: flaman jm. Cancer Res. 2020 Aug 15;80(16):3359-3371. doi: 10.1158/0008-5472.CAN-19-3763. Epub 2020 Jun 17. Cancer Res. 2020. PMID: 32554750
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging.
Ziegler DV, Vindrieux D, Goehrig D, Jaber S, Collin G, Griveau A, Wiel C, Bendridi N, Djebali S, Farfariello V, Prevarskaya N, Payen L, Marvel J, Aubert S, Flaman JM, Rieusset J, Martin N, Bernard D. Ziegler DV, et al. Among authors: flaman jm. Nat Commun. 2021 Feb 1;12(1):720. doi: 10.1038/s41467-021-20993-z. Nat Commun. 2021. PMID: 33526781 Free PMC article.
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Huna A, Griveau A, Vindrieux D, Jaber S, Flaman JM, Goehrig D, Azzi L, Médard JJ, Djebali S, Hernandez-Vargas H, Dante R, Payen L, Marvel J, Bertolino P, Aubert S, Dubus P, Bernard D. Huna A, et al. Among authors: flaman jm. Cell Death Dis. 2021 Feb 16;12(2):190. doi: 10.1038/s41419-021-03468-3. Cell Death Dis. 2021. PMID: 33594040 Free PMC article.
NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells.
Raynard C, Ma X, Huna A, Tessier N, Massemin A, Zhu K, Flaman JM, Moulin F, Goehrig D, Medard JJ, Vindrieux D, Treilleux I, Hernandez-Vargas H, Ducreux S, Martin N, Bernard D. Raynard C, et al. Among authors: flaman jm. Aging Cell. 2022 Jul;21(7):e13632. doi: 10.1111/acel.13632. Epub 2022 Jun 2. Aging Cell. 2022. PMID: 35653631 Free PMC article.
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