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IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.
iScience. 2022 Jul 20;25(8):104806. doi: 10.1016/j.isci.2022.104806. eCollection 2022 Aug 19.
iScience. 2022.
PMID: 35992082
Free PMC article.
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.
Widjaja AA, Viswanathan S, Jinrui D, Singh BK, Tan J, Wei Ting JG, Lamb D, Shekeran SG, George BL, Schafer S, Carling D, Adami E, Cook SA.
Widjaja AA, et al. Among authors: wei ting jg.
Front Mol Biosci. 2021 Sep 28;8:740650. doi: 10.3389/fmolb.2021.740650. eCollection 2021.
Front Mol Biosci. 2021.
PMID: 34651016
Free PMC article.
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