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Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas.
Zhou B, Liang X, Mei H, Qi S, Jiang Z, Wang A, Zou F, Liu Q, Liu J, Wang W, Hu C, Chen Y, Wang Z, Wang B, Wang L, Liu J, Liu Q. Zhou B, et al. Among authors: wang w, wang l, wang z, wang b, wang a. J Med Chem. 2021 Oct 28;64(20):15170-15188. doi: 10.1021/acs.jmedchem.1c01154. Epub 2021 Oct 19. J Med Chem. 2021. PMID: 34664960
Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models.
Wang L, Hu C, Wang A, Chen C, Wu J, Jiang Z, Zou F, Yu K, Wu H, Liu J, Wang W, Wang Z, Wang B, Qi Z, Liu Q, Wang W, Li L, Ge J, Liu J, Liu Q. Wang L, et al. Among authors: wang w, wang z, wang b, wang a. Invest New Drugs. 2020 Oct;38(5):1272-1281. doi: 10.1007/s10637-019-00868-3. Epub 2019 Dec 23. Invest New Drugs. 2020. PMID: 31872348
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2.
Yang J, Weisberg EL, Qi S, Ni W, Mei H, Wang Z, Meng C, Zhang S, Hou M, Qi Z, Wang A, Jiang Y, Jiang Z, Huang T, Liu Q, Magin RS, Doherty L, Wang W, Liu J, Buhrlage SJ, Liu Q, Griffin JD. Yang J, et al. Among authors: wang w, wang z, wang a. Leukemia. 2022 Apr;36(4):1048-1057. doi: 10.1038/s41375-021-01494-w. Epub 2022 Jan 17. Leukemia. 2022. PMID: 35034955
Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment.
Wang A, Liu J, Li X, Zou F, Qi Z, Qi S, Liu Q, Wang Z, Cao J, Jiang Z, Wang B, Ge J, Wang L, Wang W, Liu J, Liu Q. Wang A, et al. Among authors: wang w, wang l, wang z, wang b. Eur J Pharmacol. 2023 Aug 5;952:175752. doi: 10.1016/j.ejphar.2023.175752. Epub 2023 May 8. Eur J Pharmacol. 2023. PMID: 37164118
139,220 results
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