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114 results

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Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation.
Gao J, Gurbuxani S, Zak T, Kocherginsky M, Ji P, Wehbe F, Chen Q, Chen YH, Lu X, Jennings L, Frankfurt O, Altman J, Sukhanova M. Gao J, et al. Among authors: gurbuxani s. Genes Chromosomes Cancer. 2022 Feb;61(2):71-80. doi: 10.1002/gcc.23004. Epub 2021 Oct 28. Genes Chromosomes Cancer. 2022. PMID: 34668265
Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial.
Gangat N, Marinaccio C, Swords R, Watts JM, Gurbuxani S, Rademaker A, Fought AJ, Frankfurt O, Altman JK, Wen QJ, Farnoud N, Famulare CA, Patel A, Tapia R, Vallapureddy RR, Barath S, Graf A, Handlogten A, Zblewski D, Patnaik MM, Al-Kali A, Dinh YT, Englund Prahl K, Patel S, Nobrega JC, Tejera D, Thomassen A, Gao J, Ji P, Rampal RK, Giles FJ, Tefferi A, Stein B, Crispino JD. Gangat N, et al. Among authors: gurbuxani s. Clin Cancer Res. 2019 Aug 15;25(16):4898-4906. doi: 10.1158/1078-0432.CCR-19-1005. Epub 2019 May 6. Clin Cancer Res. 2019. PMID: 31061068
Therapy-related myeloid neoplasms with normal karyotype show distinct genomic and clinical characteristics compared to their counterparts with abnormal karyotype.
Tariq H, Barnea Slonim L, Coty Fattal Z, Alikhan MB, Segal J, Gurbuxani S, Helenowski IB, Zhang H, Sukhanova M, Lu X, Altman JK, Chen QC, Behdad A. Tariq H, et al. Among authors: gurbuxani s. Br J Haematol. 2022 Jun;197(6):736-744. doi: 10.1111/bjh.18154. Epub 2022 Mar 18. Br J Haematol. 2022. PMID: 35304738
Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms.
Kaur A, Rojek AE, Symes E, Nawas MT, Patel AA, Patel JL, Sojitra P, Aqil B, Sukhanova M, McNerney ME, Wu LP, Akmatbekov A, Segal J, Tjota MY, Gurbuxani S, Cheng JX, Yeon SY, Ravisankar HV, Fitzpatrick C, Lager A, Drazer MW, Saygin C, Wanjari P, Katsonis P, Lichtarge O, Churpek JE, Ghosh SB, Patel AB, Menon MP, Arber DA, Wang P, Venkataraman G. Kaur A, et al. Among authors: gurbuxani s. Blood Cancer J. 2024 Jun 18;14(1):99. doi: 10.1038/s41408-024-01077-9. Blood Cancer J. 2024. PMID: 38890297 Free PMC article.
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, Ren H, Kunjamma RB, Neilly MB, Salat J, Wunderlich M, Slany RK, Zhang Y, Larson RA, Le Beau MM, Mulloy JC, Rowley JD, Chen J. Jiang X, et al. Among authors: gurbuxani s. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19397-402. doi: 10.1073/pnas.1217519109. Epub 2012 Nov 6. Proc Natl Acad Sci U S A. 2012. PMID: 23132946 Free PMC article.
AKT is a therapeutic target in myeloproliferative neoplasms.
Khan I, Huang Z, Wen Q, Stankiewicz MJ, Gilles L, Goldenson B, Schultz R, Diebold L, Gurbuxani S, Finke CM, Lasho TL, Koppikar P, Pardanani A, Stein B, Altman JK, Levine RL, Tefferi A, Crispino JD. Khan I, et al. Among authors: gurbuxani s. Leukemia. 2013 Sep;27(9):1882-90. doi: 10.1038/leu.2013.167. Epub 2013 Jun 10. Leukemia. 2013. PMID: 23748344 Free PMC article.
114 results