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Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry.
Park YJ, De Marco A, Starr TN, Liu Z, Pinto D, Walls AC, Zatta F, Zepeda SK, Bowen J, Sprouse KS, Joshi A, Giurdanella M, Guarino B, Noack J, Abdelnabi R, Foo SC, Lempp FA, Benigni F, Snell G, Neyts J, Whelan SP, Virgin HW, Bloom JD, Corti D, Pizzuto MS, Veesler D. Park YJ, et al. Among authors: liu z. bioRxiv [Preprint]. 2021 Oct 14:2021.10.13.464254. doi: 10.1101/2021.10.13.464254. bioRxiv. 2021. Update in: Science. 2022 Jan 28;375(6579):449-454. doi: 10.1126/science.abm8143 PMID: 34671770 Free PMC article. Updated. Preprint.
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM, Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA, Whelan SPJ, Ding S. Zang R, et al. Among authors: liu z. Sci Immunol. 2020 May 13;5(47):eabc3582. doi: 10.1126/sciimmunol.abc3582. Sci Immunol. 2020. PMID: 32404436 Free PMC article.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Kang YL, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 Jun 15:2020.04.21.053058. doi: 10.1101/2020.04.21.053058. bioRxiv. 2020. Update in: Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20803-20813. doi: 10.1073/pnas.2007837117 PMID: 32511398 Free PMC article. Updated. Preprint.
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 May 18:2020.05.18.102038. doi: 10.1101/2020.05.18.102038. bioRxiv. 2020. Update in: Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021 PMID: 32511401 Free PMC article. Updated. Preprint.
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. SSRN [Preprint]. 2020 May 27:3606354. doi: 10.2139/ssrn.3606354. SSRN. 2020. Update in: Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021 PMID: 32714117 Free PMC article. Updated. Preprint.
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021. Epub 2020 Jul 3. Cell Host Microbe. 2020. PMID: 32735849 Free PMC article.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Kang YL, et al. Among authors: liu z. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20803-20813. doi: 10.1073/pnas.2007837117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764148 Free PMC article.
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.
Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD. Greaney AJ, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 Sep 28:2020.09.10.292078. doi: 10.1101/2020.09.10.292078. bioRxiv. 2020. Update in: Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9. doi: 10.1016/j.chom.2020.11.007 PMID: 32935107 Free PMC article. Updated. Preprint.
JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis.
Son J, Huang S, Zeng Q, Bricker TL, Case JB, Zhou J, Zang R, Liu Z, Chang X, Harastani HH, Chen L, Castro MFG, Zhao Y, Kohio HP, Hou G, Fan B, Niu B, Guo R, Rothlauf PW, Bailey AL, Wang X, Shi PY, Martinez ED, Whelan SPJ, Diamond MS, Boon ACM, Li B, Ding S. Son J, et al. Among authors: liu z. bioRxiv [Preprint]. 2021 Jun 4:2020.09.24.312165. doi: 10.1101/2020.09.24.312165. bioRxiv. 2021. Update in: mBio. 2022 Jan 18;13(1):e0337721. doi: 10.1128/mbio.03377-21 PMID: 32995798 Free PMC article. Updated. Preprint.
Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.
Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD. Greaney AJ, et al. Among authors: liu z. Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9. doi: 10.1016/j.chom.2020.11.007. Epub 2020 Nov 19. Cell Host Microbe. 2021. PMID: 33259788 Free PMC article.
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