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Page 1
Efficacy and safety of oral ibrexafungerp for the treatment of acute vulvovaginal candidiasis: a global phase 3, randomised, placebo-controlled superiority study (VANISH 306).
Sobel R, Nyirjesy P, Ghannoum MA, Delchev DA, Azie NE, Angulo D, Harriott IA, Borroto-Esoda K, Sobel JD. Sobel R, et al. Among authors: angulo d. BJOG. 2022 Feb;129(3):412-420. doi: 10.1111/1471-0528.16972. Epub 2021 Nov 8. BJOG. 2022. PMID: 34676663 Free PMC article. Clinical Trial.
SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies.
Scorneaux B, Angulo D, Borroto-Esoda K, Ghannoum M, Peel M, Wring S. Scorneaux B, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01961-16. doi: 10.1128/AAC.01961-16. Print 2017 Mar. Antimicrob Agents Chemother. 2017. PMID: 28069658 Free PMC article.
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.
Wring SA, Randolph R, Park S, Abruzzo G, Chen Q, Flattery A, Garrett G, Peel M, Outcalt R, Powell K, Trucksis M, Angulo D, Borroto-Esoda K. Wring SA, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02068-16. doi: 10.1128/AAC.02068-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28137806 Free PMC article.
The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.
Larkin E, Hager C, Chandra J, Mukherjee PK, Retuerto M, Salem I, Long L, Isham N, Kovanda L, Borroto-Esoda K, Wring S, Angulo D, Ghannoum M. Larkin E, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02396-16. doi: 10.1128/AAC.02396-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223375 Free PMC article.
De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance.
Jiménez-Ortigosa C, Perez WB, Angulo D, Borroto-Esoda K, Perlin DS. Jiménez-Ortigosa C, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00833-17. doi: 10.1128/AAC.00833-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28630180 Free PMC article.
Evaluation of the Antifungal Activity of the Novel Oral Glucan Synthase Inhibitor SCY-078, Singly and in Combination, for the Treatment of Invasive Aspergillosis.
Ghannoum M, Long L, Larkin EL, Isham N, Sherif R, Borroto-Esoda K, Barat S, Angulo D. Ghannoum M, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2018 May 25;62(6):e00244-18. doi: 10.1128/AAC.00244-18. Print 2018 Jun. Antimicrob Agents Chemother. 2018. PMID: 29610204 Free PMC article.
SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [14C]SCY-078 in Albino and Pigmented Rats.
Wring S, Borroto-Esoda K, Solon E, Angulo D. Wring S, et al. Among authors: angulo d. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e02119-18. doi: 10.1128/AAC.02119-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30478166 Free PMC article.
68 results