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Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells.
Bigelyte G, Young JK, Karvelis T, Budre K, Zedaveinyte R, Djukanovic V, Van Ginkel E, Paulraj S, Gasior S, Jones S, Feigenbutz L, Clair GS, Barone P, Bohn J, Acharya A, Zastrow-Hayes G, Henkel-Heinecke S, Silanskas A, Seidel R, Siksnys V. Bigelyte G, et al. Among authors: budre k. Nat Commun. 2021 Oct 26;12(1):6191. doi: 10.1038/s41467-021-26469-4. Nat Commun. 2021. PMID: 34702830 Free PMC article.
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas Č, Siksnys V. Karvelis T, et al. Among authors: budre k. Nature. 2021 Nov;599(7886):692-696. doi: 10.1038/s41586-021-04058-1. Epub 2021 Oct 7. Nature. 2021. PMID: 34619744 Free PMC article.
Non-cell-autonomous cancer progression from chromosomal instability.
Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF. Li J, et al. Among authors: budre k. Nature. 2023 Aug;620(7976):1080-1088. doi: 10.1038/s41586-023-06464-z. Epub 2023 Aug 23. Nature. 2023. PMID: 37612508 Free PMC article.