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Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells.
Bigelyte G, Young JK, Karvelis T, Budre K, Zedaveinyte R, Djukanovic V, Van Ginkel E, Paulraj S, Gasior S, Jones S, Feigenbutz L, Clair GS, Barone P, Bohn J, Acharya A, Zastrow-Hayes G, Henkel-Heinecke S, Silanskas A, Seidel R, Siksnys V. Bigelyte G, et al. Among authors: siksnys v. Nat Commun. 2021 Oct 26;12(1):6191. doi: 10.1038/s41467-021-26469-4. Nat Commun. 2021. PMID: 34702830 Free PMC article.
Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors.
Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M. Schmitz C, et al. Among authors: siksnys v. Nucleic Acids Res. 2022 Nov 28;50(21):12558-12577. doi: 10.1093/nar/gkac1103. Nucleic Acids Res. 2022. PMID: 36464236 Free PMC article.
Photocaged variants of the MunI and PvuII restriction enzymes.
Silanskas A, Foss M, Wende W, Urbanke C, Lagunavicius A, Pingoud A, Siksnys V. Silanskas A, et al. Among authors: siksnys v. Biochemistry. 2011 Apr 12;50(14):2800-7. doi: 10.1021/bi2000609. Epub 2011 Mar 16. Biochemistry. 2011. PMID: 21410225
Programmable DNA cleavage in vitro by Cas9.
Karvelis T, Gasiunas G, Siksnys V. Karvelis T, et al. Among authors: siksnys v. Biochem Soc Trans. 2013 Dec;41(6):1401-6. doi: 10.1042/BST20130164. Biochem Soc Trans. 2013. PMID: 24256227 Review.
133 results