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Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Among authors: bombardi rg. Cell. 2021 Oct 28;184(22):5593-5607.e18. doi: 10.1016/j.cell.2021.09.035. Cell. 2021. PMID: 34715022 Free PMC article.
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE Jr. Gilchuk P, et al. Among authors: bombardi rg. Immunity. 2018 Aug 21;49(2):363-374.e10. doi: 10.1016/j.immuni.2018.06.018. Epub 2018 Jul 17. Immunity. 2018. PMID: 30029854 Free PMC article.
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Among authors: bombardi rg. Immunity. 2020 Feb 18;52(2):388-403.e12. doi: 10.1016/j.immuni.2020.01.001. Epub 2020 Feb 4. Immunity. 2020. PMID: 32023489 Free PMC article.
Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein.
Dong J, Cross RW, Doyle MP, Kose N, Mousa JJ, Annand EJ, Borisevich V, Agans KN, Sutton R, Nargi R, Majedi M, Fenton KA, Reichard W, Bombardi RG, Geisbert TW, Crowe JE Jr. Dong J, et al. Among authors: bombardi rg. Cell. 2020 Dec 10;183(6):1536-1550.e17. doi: 10.1016/j.cell.2020.11.023. Cell. 2020. PMID: 33306954 Free PMC article.
Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.
Gilchuk P, Guthals A, Bonissone SR, Shaw JB, Ilinykh PA, Huang K, Bombardi RG, Liang J, Grinyo A, Davidson E, Chen EC, Gunn BM, Alter G, Saphire EO, Doranz BJ, Bukreyev A, Zeitlin L, Castellana N, Crowe JE Jr. Gilchuk P, et al. Among authors: bombardi rg. Front Immunol. 2021 Jul 16;12:706757. doi: 10.3389/fimmu.2021.706757. eCollection 2021. Front Immunol. 2021. PMID: 34335620 Free PMC article.
Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.
Williamson LE, Gilliland T Jr, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe JE Jr. Williamson LE, et al. Cell. 2020 Dec 23;183(7):1884-1900.e23. doi: 10.1016/j.cell.2020.11.011. Epub 2020 Dec 9. Cell. 2020. PMID: 33301709 Free PMC article.
Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr. Zost SJ, et al. J Clin Invest. 2021 Aug 2;131(15):e146791. doi: 10.1172/JCI146791. J Clin Invest. 2021. PMID: 34156974 Free PMC article.
Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein.
Doyle MP, Kose N, Borisevich V, Binshtein E, Amaya M, Nagel M, Annand EJ, Armstrong E, Bombardi R, Dong J, Schey KL, Broder CC, Zeitlin L, Kuang EA, Bornholdt ZA, West BR, Geisbert TW, Cross RW, Crowe JE Jr. Doyle MP, et al. Cell Rep. 2021 Aug 31;36(9):109628. doi: 10.1016/j.celrep.2021.109628. Cell Rep. 2021. PMID: 34469726 Free PMC article.
37 results