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Page 1
Design of High-Affinity Metal-Controlled Protein Dimers.
Maniaci B, Lipper CH, Anipindi DL, Erlandsen H, Cole JL, Stec B, Huxford T, Love JJ. Maniaci B, et al. Among authors: lipper ch. Biochemistry. 2019 Apr 30;58(17):2199-2207. doi: 10.1021/acs.biochem.9b00055. Epub 2019 Apr 12. Biochemistry. 2019. PMID: 30938154
A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R. Tamir S, et al. Among authors: lipper ch. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1572-8. doi: 10.1107/S1399004714005458. Epub 2014 May 23. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914968 Free PMC article.
Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.
Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings PA, Mittler R, Nechushtai R. Tamir S, et al. Among authors: lipper ch. Biochim Biophys Acta. 2015 Jun;1853(6):1294-315. doi: 10.1016/j.bbamcr.2014.10.014. Epub 2014 Oct 23. Biochim Biophys Acta. 2015. PMID: 25448035 Free article. Review.
Molecular Dynamics Simulations of the [2Fe-2S] Cluster-Binding Domain of NEET Proteins Reveal Key Molecular Determinants That Induce Their Cluster Transfer/Release.
Pesce L, Calandrini V, Marjault HB, Lipper CH, Rossetti G, Mittler R, Jennings PA, Bauer A, Nechushtai R, Carloni P. Pesce L, et al. Among authors: lipper ch. J Phys Chem B. 2017 Nov 30;121(47):10648-10656. doi: 10.1021/acs.jpcb.7b10584. Epub 2017 Nov 16. J Phys Chem B. 2017. PMID: 29086562 Free PMC article.
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. Tamir S, et al. Among authors: lipper ch. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5177-82. doi: 10.1073/pnas.1403770111. Epub 2014 Mar 25. Proc Natl Acad Sci U S A. 2014. PMID: 24706857 Free PMC article.
The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.
Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings PA, Onuchic JN, Mittler R, Nechushtai R. Bai F, et al. Among authors: lipper ch. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3698-703. doi: 10.1073/pnas.1502960112. Epub 2015 Mar 11. Proc Natl Acad Sci U S A. 2015. PMID: 25762074 Free PMC article.
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