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Page 1
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth.
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez-Escudero J, Casado P, Rajeeve V, Reynolds LE, R Cutillas P, Duffy SW, De Luxán Delgado B, Hodivala-Dilke K. Newport E, et al. Among authors: gomez escudero j. J Pathol. 2022 Feb;256(2):235-247. doi: 10.1002/path.5833. Epub 2021 Dec 20. J Pathol. 2022. PMID: 34743335
Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.
Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM. Pedrosa AR, et al. Among authors: gomez escudero j. Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12. Cancer Res. 2019. PMID: 31189647
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker AM, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P, Hodivala-Dilke K. Demircioglu F, et al. Among authors: gomez escudero j. Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3. Nat Commun. 2020. PMID: 32157087 Free PMC article.
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D'Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM. Lechertier T, et al. Among authors: gomez escudero j. Nat Commun. 2020 Jun 4;11(1):2810. doi: 10.1038/s41467-020-16618-6. Nat Commun. 2020. PMID: 32499572 Free PMC article.
Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.
Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG, Gómez-Escudero J, Richards FM, Weller C, Dormann C, Meng YM, Vermeulen PB, Saur D, Sanz-Moreno V, Wong PP, Géraud C, Cutillas PR, Hodivala-Dilke K. Roy-Luzarraga M, et al. Among authors: gomez escudero j. Cancer Res. 2022 May 16;82(10):1909-1925. doi: 10.1158/0008-5472.CAN-20-3807. Cancer Res. 2022. PMID: 35350066 Free PMC article.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B, Serrels A, Parsons M, Squire A, Birdsey GM, Randi AM, Bolado-Carrancio A, Gangeswaran R, Reynolds LE, Bodrug N, Wang Y, Wang J, Meier P, Hodivala-Dilke KM. D'Amico G, et al. Among authors: gomez escudero j. Development. 2022 Jul 1;149(13):dev200528. doi: 10.1242/dev.200528. Epub 2022 Jul 12. Development. 2022. PMID: 35723257 Free PMC article.
Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D'Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM. Lechertier T, et al. Among authors: gomez escudero j. Nat Commun. 2023 Sep 6;14(1):5446. doi: 10.1038/s41467-023-41239-0. Nat Commun. 2023. PMID: 37673931 Free PMC article. No abstract available.
An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.
Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG. Moreno V, et al. J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. doi: 10.1242/jcs.149518. Epub 2014 Jul 2. J Cell Sci. 2014. PMID: 24994937 Free PMC article.
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